J 2016

c-MET-mediated resistance to EGFR inhibitors in head and neck cancer: How to move from bench to bedside

SZTURZ, Petr, E. RAYMOND and S. FAIVRE

Basic information

Original name

c-MET-mediated resistance to EGFR inhibitors in head and neck cancer: How to move from bench to bedside

Authors

SZTURZ, Petr (203 Czech Republic, guarantor, belonging to the institution), E. RAYMOND (250 France) and S. FAIVRE (250 France)

Edition

Oral oncology, AMSTERDAM, ELSEVIER SCIENCE BV, 2016, 1368-8375

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 4.794

RIV identification code

RIV/00216224:14110/16:00090826

Organization unit

Faculty of Medicine

UT WoS

000380544000005

Keywords in English

squamous-cell carcinoma; randomized phase-ii; tivantinib arq 197; lung-cancer; acquired-resistance; metastatic head; plus erlotinib; double-blind; patients pts; placebo

Tags

Tags

International impact, Reviewed
Změněno: 15/9/2016 15:09, Soňa Böhmová

Abstract

V originále

Mesenchymal–epithelial transition factor (c-MET), found on melanocytes, endothelial cells, and epithelial tissues, is a membrane spanning receptor tyrosine kinase for hepatocyte growth factor (HGF), produced by elements of mesenchymal origin. The receptor-ligand pair controls diverse biological activities including cell proliferation, motility, invasiveness, morphogenesis, apoptosis, and angiogenesis.