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@proceedings{1354670,
author = {Malinovská, Lenka and Kašáková, Martina and Moravcová, Jitka and Wimmerová, Michaela},
booktitle = {XXV. Biochemický sjezd},
keywords = {lectins; cystic fibrosis; inhibitors; hemagglutination},
language = {eng},
isbn = {978-80-270-0331-0},
title = {Multivalent Carbohydrate-based Inhibitors of Lectins},
year = {2016}
}
TY - CONF
ID - 1354670
AU - Malinovská, Lenka - Kašáková, Martina - Moravcová, Jitka - Wimmerová, Michaela
PY - 2016
TI - Multivalent Carbohydrate-based Inhibitors of Lectins
SN - 9788027003310
KW - lectins
KW - cystic fibrosis
KW - inhibitors
KW - hemagglutination
N2 - Lectins are sugar-binding proteins of non-immune origin occurring in all organisms and executing various functions. Microbial lectins can recognize carbohydrates on host cells (glycoproteins or glycolipids) and mediate adhesion to host cells or mucosal surfaces. Adhesion is considered to be an important step in the infection development as it protects a pathogen from natural cleansing mechanisms of the host. Consequently, lectins could be significant virulence factors. Therefore, blocking of adhesion could prevent disease development or facilitate treatment. Our most promising results were obtained for L-fucose-specific lectins AFL from A. fumigatus (the most prominent fungal human pathogen causing nosocomial infections) and RSL from R. solanacearum (a dangerous pathogen of important agricultural plants). The inhibition potencies of carbohydrate-based inhibitors with a calixarene core were significantly higher than that of a simple fucose monosaccharide.
ER -
MALINOVSKÁ, Lenka, Martina KAŠÁKOVÁ, Jitka MORAVCOVÁ and Michaela WIMMEROVÁ. Multivalent Carbohydrate-based Inhibitors of Lectins. In \textit{XXV. Biochemický sjezd}. 2016. ISBN~978-80-270-0331-0.
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