| BALIAKAS, Panagiotis, Anna PUIGGROS, Aliki XOCHELLI, Lesley-Ann SUTTON, Florence NGUYEN-KHAC, Anne GARDINER, Karla PLEVOVÁ, Eva MINGA, Anastasia HADZIDIMITRIOU, Renata WALEWSKA, Helen MCCARTHY, Margarita ORTEGA, Rosa COLLADO, Teresa GONZALEZ, Isabel GRANADA, Elisa LUNO, Jana KOTAŠKOVÁ, Theodoros MOYSIADIS, Zadie DAVIS, Niki STAVROYIANNI, Achilles ANAGNOSTOPOULOS, Jonathan C. STREFFORD, Šárka POSPÍŠILOVÁ, Frederic DAVI, Anastasia ATHANASIADOU, Richard ROSENQUIST, David OSCIER, Blanca ESPINET and Kostas STAMATOPOULOS. Additional trisomies amongst patients with chronic lymphocytic leukemia carrying trisomy 12: the accompanying chromosome makes a difference. Haematologica. PAVIA: FERRATA STORTI FOUNDATION, 2016, vol. 101, No 7, p. 299-302. ISSN 0390-6078. Available from: https://dx.doi.org/10.3324/haematol.2015.140202. |
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@article{1355344,
author = {Baliakas, Panagiotis and Puiggros, Anna and Xochelli, Aliki and Sutton, LesleyandAnn and NguyenandKhac, Florence and Gardiner, Anne and Plevová, Karla and Minga, Eva and Hadzidimitriou, Anastasia and Walewska, Renata and McCarthy, Helen and Ortega, Margarita and Collado, Rosa and Gonzalez, Teresa and Granada, Isabel and Luno, Elisa and Kotašková, Jana and Moysiadis, Theodoros and Davis, Zadie and Stavroyianni, Niki and Anagnostopoulos, Achilles and Strefford, Jonathan C. and Pospíšilová, Šárka and Davi, Frederic and Athanasiadou, Anastasia and Rosenquist, Richard and Oscier, David and Espinet, Blanca and Stamatopoulos, Kostas},
article_location = {PAVIA},
article_number = {7},
doi = {http://dx.doi.org/10.3324/haematol.2015.140202},
keywords = {RBC; cord blood; bio-engineered; native; metabolic profile},
language = {eng},
issn = {0390-6078},
journal = {Haematologica},
title = {Additional trisomies amongst patients with chronic lymphocytic leukemia carrying trisomy 12: the accompanying chromosome makes a difference},
url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004477/pdf/101e299.pdf},
volume = {101},
year = {2016}
}
TY - JOUR
ID - 1355344
AU - Baliakas, Panagiotis - Puiggros, Anna - Xochelli, Aliki - Sutton, Lesley-Ann - Nguyen-Khac, Florence - Gardiner, Anne - Plevová, Karla - Minga, Eva - Hadzidimitriou, Anastasia - Walewska, Renata - McCarthy, Helen - Ortega, Margarita - Collado, Rosa - Gonzalez, Teresa - Granada, Isabel - Luno, Elisa - Kotašková, Jana - Moysiadis, Theodoros - Davis, Zadie - Stavroyianni, Niki - Anagnostopoulos, Achilles - Strefford, Jonathan C. - Pospíšilová, Šárka - Davi, Frederic - Athanasiadou, Anastasia - Rosenquist, Richard - Oscier, David - Espinet, Blanca - Stamatopoulos, Kostas
PY - 2016
TI - Additional trisomies amongst patients with chronic lymphocytic leukemia carrying trisomy 12: the accompanying chromosome makes a difference
JF - Haematologica
VL - 101
IS - 7
SP - 299-302
EP - 299-302
PB - FERRATA STORTI FOUNDATION
SN - 03906078
KW - RBC
KW - cord blood
KW - bio-engineered
KW - native
KW - metabolic profile
UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004477/pdf/101e299.pdf
L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004477/pdf/101e299.pdf
N2 - Recurrent cytogenetic abnormalities in chronic lym- phocytic leukemia (CLL), namely deletions of chromo- somes 11q, 13q, 17p and trisomy 12 (+12), define sub- groups of patients with different clinical behavior and response to treatment. 1 We and others previously report- ed a minor proportion of CLL cases with co-existing tri- somies of chromosomes 12 and 19 who share specific clinico-biological characteristics. 2-4 However, since the cohort was small, no definitive conclusions could be drawn. Here, we analyzed a large, multi-institutional series. We confirm and significantly extend previous observations through the identification of subgroups of +12 CLL cases harboring particular concurrent trisomies demonstrating distinctive clinico-biological profiles. We analyzed an unselected cohort of 4486 CLL patients with available classic cytogenetic (n=4285) or high-density 250K single nucleotide polymorphism (SNP)-array (n=201) data. We identified 712 cases (16% of the cohort) carrying +12. 5 Median time from diagnosis to cytogenet- ic/SNP analysis was 1.5 months (range 0-194); the major- ity of cases included in survival analysis were untreated prior to testing (94%). The study was approved by the local Ethics Review Committees. Details of the study cohort and the methodologies used are provided in the Online Supplementary Appendix.
ER -
BALIAKAS, Panagiotis, Anna PUIGGROS, Aliki XOCHELLI, Lesley-Ann SUTTON, Florence NGUYEN-KHAC, Anne GARDINER, Karla PLEVOVÁ, Eva MINGA, Anastasia HADZIDIMITRIOU, Renata WALEWSKA, Helen MCCARTHY, Margarita ORTEGA, Rosa COLLADO, Teresa GONZALEZ, Isabel GRANADA, Elisa LUNO, Jana KOTAŠKOVÁ, Theodoros MOYSIADIS, Zadie DAVIS, Niki STAVROYIANNI, Achilles ANAGNOSTOPOULOS, Jonathan C. STREFFORD, Šárka POSPÍŠILOVÁ, Frederic DAVI, Anastasia ATHANASIADOU, Richard ROSENQUIST, David OSCIER, Blanca ESPINET and Kostas STAMATOPOULOS. Additional trisomies amongst patients with chronic lymphocytic leukemia carrying trisomy 12: the accompanying chromosome makes a difference. \textit{Haematologica}. PAVIA: FERRATA STORTI FOUNDATION, 2016, vol.~101, No~7, p.~299-302. ISSN~0390-6078. Available from: https://dx.doi.org/10.3324/haematol.2015.140202.
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