Detailed Information on Publication Record
2016
Hippocampal volume in first-episode schizophrenia and longitudinal course of the illness
HÝŽA, Martin, Matyáš KUHN, Eva ČEŠKOVÁ, Libor USTOHAL, Tomáš KAŠPÁREK et. al.Basic information
Original name
Hippocampal volume in first-episode schizophrenia and longitudinal course of the illness
Authors
HÝŽA, Martin (203 Czech Republic, guarantor, belonging to the institution), Matyáš KUHN (203 Czech Republic, belonging to the institution), Eva ČEŠKOVÁ (203 Czech Republic, belonging to the institution), Libor USTOHAL (203 Czech Republic, belonging to the institution) and Tomáš KAŠPÁREK (203 Czech Republic, belonging to the institution)
Edition
World Journal of Biological Psychiatry, Abingdon, Taylor & Francis LTD, 2016, 1562-2975
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30000 3. Medical and Health Sciences
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 3.658
RIV identification code
RIV/00216224:14110/16:00091001
Organization unit
Faculty of Medicine
UT WoS
000383408000003
Keywords in English
atrophy; hippocampus; predisposition; Schizophrenia; toxicity
Tags
International impact, Reviewed
Změněno: 24/10/2016 15:20, Ing. Mgr. Věra Pospíšilíková
Abstract
V originále
Objectives: Several lines of evidence suggest an adverse effect of psychotic episodes on brain morphology. It is not clear if this relationship reflects the cumulative effect of psychotic outbursts on the gradual progressive reduction of hippocampal tissue or an increased tendency toward psychotic episodes in patients with a smaller hippocampus at the beginning of the illness. Methods: This is a longitudinal 4-year prospective study of patients with first-episode schizophrenia (FES, N = 58). Baseline brain anatomical scans (at FES) were analysed using voxel-based morphometry and atlas-based volumetry of the hippocampal subfields. The effects of first-episode duration on the hippocampal morphology, and the effect of baseline hippocampal morphology on illness course with relapses, number of psychotic episodes and residual symptoms were analysed. Results: A significant negative correlation was detected between first-episode duration and baseline hippocampal morphology. Relapse, number of psychotic episodes and residual symptoms had no correlation with baseline hippocampal volume. Conclusions: We replicated the effect of psychosis duration on hippocampal volume already at the time first-episode, which supports the concept of toxicity of psychosis. The indices of a later unfavourable course of schizophrenia had no correlation with baseline brain morphology, suggesting that there is no baseline morphological abnormality of the hippocampus that predisposes the patient to frequent psychotic outbursts.
Links
| ED1.1.00/02.0068, research and development project |
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