| HÝŽA, Martin, Matyáš KUHN, Eva ČEŠKOVÁ, Libor USTOHAL and Tomáš KAŠPÁREK. Hippocampal volume in first-episode schizophrenia and longitudinal course of the illness. World Journal of Biological Psychiatry. Abingdon: Taylor & Francis LTD, 2016, vol. 17, No 6, p. 429-438. ISSN 1562-2975. Available from: https://dx.doi.org/10.1080/15622975.2016.1199893. |
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@article{1355457,
author = {Hýža, Martin and Kuhn, Matyáš and Češková, Eva and Ustohal, Libor and Kašpárek, Tomáš},
article_location = {Abingdon},
article_number = {6},
doi = {http://dx.doi.org/10.1080/15622975.2016.1199893},
keywords = {atrophy; hippocampus; predisposition; Schizophrenia; toxicity},
language = {eng},
issn = {1562-2975},
journal = {World Journal of Biological Psychiatry},
title = {Hippocampal volume in first-episode schizophrenia and longitudinal course of the illness},
volume = {17},
year = {2016}
}
TY - JOUR
ID - 1355457
AU - Hýža, Martin - Kuhn, Matyáš - Češková, Eva - Ustohal, Libor - Kašpárek, Tomáš
PY - 2016
TI - Hippocampal volume in first-episode schizophrenia and longitudinal course of the illness
JF - World Journal of Biological Psychiatry
VL - 17
IS - 6
SP - 429-438
EP - 429-438
PB - Taylor & Francis LTD
SN - 15622975
KW - atrophy
KW - hippocampus
KW - predisposition
KW - Schizophrenia
KW - toxicity
N2 - Objectives: Several lines of evidence suggest an adverse effect of psychotic episodes on brain morphology. It is not clear if this relationship reflects the cumulative effect of psychotic outbursts on the gradual progressive reduction of hippocampal tissue or an increased tendency toward psychotic episodes in patients with a smaller hippocampus at the beginning of the illness. Methods: This is a longitudinal 4-year prospective study of patients with first-episode schizophrenia (FES, N = 58). Baseline brain anatomical scans (at FES) were analysed using voxel-based morphometry and atlas-based volumetry of the hippocampal subfields. The effects of first-episode duration on the hippocampal morphology, and the effect of baseline hippocampal morphology on illness course with relapses, number of psychotic episodes and residual symptoms were analysed. Results: A significant negative correlation was detected between first-episode duration and baseline hippocampal morphology. Relapse, number of psychotic episodes and residual symptoms had no correlation with baseline hippocampal volume. Conclusions: We replicated the effect of psychosis duration on hippocampal volume already at the time first-episode, which supports the concept of toxicity of psychosis. The indices of a later unfavourable course of schizophrenia had no correlation with baseline brain morphology, suggesting that there is no baseline morphological abnormality of the hippocampus that predisposes the patient to frequent psychotic outbursts.
ER -
HÝŽA, Martin, Matyáš KUHN, Eva ČEŠKOVÁ, Libor USTOHAL and Tomáš KAŠPÁREK. Hippocampal volume in first-episode schizophrenia and longitudinal course of the illness. \textit{World Journal of Biological Psychiatry}. Abingdon: Taylor \&{} Francis LTD, 2016, vol.~17, No~6, p.~429-438. ISSN~1562-2975. Available from: https://dx.doi.org/10.1080/15622975.2016.1199893.
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