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@article{1355845, author = {Goüy de Bellocq, Joëlle and Těšíková, Jana and Meheretu, Yonas and Čížková, Dagmar and Bryjová, Anna and Leirs, Herwig and Bryja, Josef}, article_location = {Amsterdam}, article_number = {November}, doi = {http://dx.doi.org/10.1016/j.meegid.2016.09.009}, keywords = {Hantavirus; Murinae; Ethiopia; High throughput sequencing; Genomics}, language = {eng}, issn = {1567-1348}, journal = {Infection, Genetics and Evolution}, title = {Complete genome characterisation and phylogenetic position of Tigray hantavirus from the Ethiopian white-footed mouse, Stenocephalemys albipes}, volume = {45}, year = {2016} }
TY - JOUR ID - 1355845 AU - Goüy de Bellocq, Joëlle - Těšíková, Jana - Meheretu, Yonas - Čížková, Dagmar - Bryjová, Anna - Leirs, Herwig - Bryja, Josef PY - 2016 TI - Complete genome characterisation and phylogenetic position of Tigray hantavirus from the Ethiopian white-footed mouse, Stenocephalemys albipes JF - Infection, Genetics and Evolution VL - 45 IS - November SP - 242-245 EP - 242-245 PB - Elsevier Science SN - 15671348 KW - Hantavirus KW - Murinae KW - Ethiopia KW - High throughput sequencing KW - Genomics N2 - Hantaviruses, well-known human pathogens, have only recently been identified on the African continent. Tigray virus (TIGV) was found in Ethiopia in 2012 in a Murinae species, Stenocephalemys albipes, but the genetic data obtained at that time were too limited to correctly assess its phylogenetic position within the hantavirus tree. We used high throughput sequencing to determine the complete genome of TIGV, which showed a typical hantavirus organisation. The large (L), medium (M), and small (S) genome segments were found to be 6532, 3594 and 1908 nucleotides long, respectively, and the 5' and 3' termini for all three segments were predicted to form the panhandle-like structure typical for bunyaviruses. Nucleotide-based phylogenetic analyses revealed that all three coding segments cluster in the phylogroup III sensu Guo et al. (2013). However, while TIGV S segment is basal to the Murinae-associated hantaviruses, the M and L segments are basal to the Soricomorpha-associated hantaviruses. TIGV is the first Murinae-borne hantavirus showing this inconsistent segmental clustering in the hantavirus phylogenetic tree. We finally propose non-exclusive scenarios that could explain the original phylogenetic position of TIGV. (C) 2016 Elsevier B.V. All rights reserved. ER -
GOÜY DE BELLOCQ, Jo$\backslash$''elle, Jana TĚŠÍKOVÁ, Yonas MEHERETU, Dagmar ČÍŽKOVÁ, Anna BRYJOVÁ, Herwig LEIRS and Josef BRYJA. Complete genome characterisation and phylogenetic position of Tigray hantavirus from the Ethiopian white-footed mouse, Stenocephalemys albipes. \textit{Infection, Genetics and Evolution}. Amsterdam: Elsevier Science, 2016, vol.~45, November, p.~242-245. ISSN~1567-1348. Available from: https://dx.doi.org/10.1016/j.meegid.2016.09.009.
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