Detailed Information on Publication Record
2016
Complete genome characterisation and phylogenetic position of Tigray hantavirus from the Ethiopian white-footed mouse, Stenocephalemys albipes
GOÜY DE BELLOCQ, Joëlle, Jana TĚŠÍKOVÁ, Yonas MEHERETU, Dagmar ČÍŽKOVÁ, Anna BRYJOVÁ et. al.Basic information
Original name
Complete genome characterisation and phylogenetic position of Tigray hantavirus from the Ethiopian white-footed mouse, Stenocephalemys albipes
Authors
GOÜY DE BELLOCQ, Joëlle (250 France), Jana TĚŠÍKOVÁ (203 Czech Republic, belonging to the institution), Yonas MEHERETU (231 Ethiopia), Dagmar ČÍŽKOVÁ (203 Czech Republic), Anna BRYJOVÁ (203 Czech Republic), Herwig LEIRS (56 Belgium) and Josef BRYJA (203 Czech Republic, guarantor, belonging to the institution)
Edition
Infection, Genetics and Evolution, Amsterdam, Elsevier Science, 2016, 1567-1348
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10700 1.7 Other natural sciences
Country of publisher
Netherlands
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 2.885
RIV identification code
RIV/00216224:14310/16:00095886
Organization unit
Faculty of Science
UT WoS
000388574400032
Keywords in English
Hantavirus; Murinae; Ethiopia; High throughput sequencing; Genomics
Tags
International impact, Reviewed
Změněno: 13/4/2018 12:59, Ing. Nicole Zrilić
Abstract
V originále
Hantaviruses, well-known human pathogens, have only recently been identified on the African continent. Tigray virus (TIGV) was found in Ethiopia in 2012 in a Murinae species, Stenocephalemys albipes, but the genetic data obtained at that time were too limited to correctly assess its phylogenetic position within the hantavirus tree. We used high throughput sequencing to determine the complete genome of TIGV, which showed a typical hantavirus organisation. The large (L), medium (M), and small (S) genome segments were found to be 6532, 3594 and 1908 nucleotides long, respectively, and the 5' and 3' termini for all three segments were predicted to form the panhandle-like structure typical for bunyaviruses. Nucleotide-based phylogenetic analyses revealed that all three coding segments cluster in the phylogroup III sensu Guo et al. (2013). However, while TIGV S segment is basal to the Murinae-associated hantaviruses, the M and L segments are basal to the Soricomorpha-associated hantaviruses. TIGV is the first Murinae-borne hantavirus showing this inconsistent segmental clustering in the hantavirus phylogenetic tree. We finally propose non-exclusive scenarios that could explain the original phylogenetic position of TIGV. (C) 2016 Elsevier B.V. All rights reserved.