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@article{1355877,
author = {Silva, Sonia and Altmannová, Veronika and LukeandGlaser, Sarah and Henriksen, Peter and Gallina, Irene and Yang, Xuejiao and Choudhary, Chunaram and Luke, Brian and Krejčí, Lumír and Lisby, Michael},
article_location = {Cold Spring Harbor},
article_number = {6},
doi = {http://dx.doi.org/10.1101/gad.276204.115},
keywords = {homologous recombination; telomere maintenance; genome integrity; DNA repair; Mph1; Mte1},
language = {eng},
issn = {0890-9369},
journal = {Genes & Development},
title = {Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance},
volume = {30},
year = {2016}
}
TY - JOUR
ID - 1355877
AU - Silva, Sonia - Altmannová, Veronika - Luke-Glaser, Sarah - Henriksen, Peter - Gallina, Irene - Yang, Xuejiao - Choudhary, Chunaram - Luke, Brian - Krejčí, Lumír - Lisby, Michael
PY - 2016
TI - Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance
JF - Genes & Development
VL - 30
IS - 6
SP - 700-717
EP - 700-717
PB - Cold Spring Harbor Laboratory Pres
SN - 08909369
KW - homologous recombination
KW - telomere maintenance
KW - genome integrity
KW - DNA repair
KW - Mph1
KW - Mte1
N2 - Mph1 is a member of the conserved FANCM family of DNA motor proteins that play key roles in genome maintenance processes underlying Fanconi anemia, a cancer predisposition syndrome in humans. Here, we identify Mte1 as a novel interactor of the Mph1 helicase in Saccharomyces cerevisiae. In vitro, Mte1 (Mph1-associated telomere maintenance protein 1) binds directly to DNA with a preference for branched molecules such as D loops and fork structures. In addition, Mte1 stimulates the helicase and fork regression activities of Mph1 while inhibiting the ability of Mph1 to dissociate recombination intermediates. Deletion of MTE1 reduces crossover recombination and suppresses the sensitivity of mph1 Delta mutant cells to replication stress. Mph1 and Mte1 interdependently colocalize at DNA damage-induced foci and dysfunctional telomeres, and MTE1 deletion results in elongated telomeres. Taken together, our data indicate that Mte1 plays a role in regulation of crossover recombination, response to replication stress, and telomere maintenance.
ER -
SILVA, Sonia, Veronika ALTMANNOVÁ, Sarah LUKE-GLASER, Peter HENRIKSEN, Irene GALLINA, Xuejiao YANG, Chunaram CHOUDHARY, Brian LUKE, Lumír KREJČÍ and Michael LISBY. Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance. \textit{Genes \&{} Development}. Cold Spring Harbor: Cold Spring Harbor Laboratory Pres, 2016, vol.~30, No~6, p.~700-717. ISSN~0890-9369. Available from: https://dx.doi.org/10.1101/gad.276204.115.
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