Detailed Information on Publication Record
2016
DNA, the central molecule of aging
LÉNÁRT, Peter and Lumír KREJČÍBasic information
Original name
DNA, the central molecule of aging
Authors
LÉNÁRT, Peter (703 Slovakia, belonging to the institution) and Lumír KREJČÍ (203 Czech Republic, guarantor, belonging to the institution)
Edition
Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis, Amsterdam, Elsevier Science BV, 2016, 0027-5107
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
Genetics and molecular biology
Country of publisher
Netherlands
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 1.829
RIV identification code
RIV/00216224:14110/16:00088202
Organization unit
Faculty of Medicine
UT WoS
000371986800001
Keywords in English
DNA; Aging; Chromatin structure; Telomeres; DNA damage; DNA repair; Mutagenesis
Tags
International impact, Reviewed
Změněno: 19/10/2016 10:50, Ing. Mgr. Věra Pospíšilíková
Abstract
V originále
Understanding the molecular mechanism of aging could have enormous medical implications. Despite a century of research, however, there is no universally accepted theory regarding the molecular basis of aging. On the other hand, there is plentiful evidence suggesting that DNA constitutes the central molecule in this process. Here, we review the roles of chromatin structure, DNA damage, and shortening of telomeres in aging and propose a hypothesis for how their interplay leads to aging phenotypes.
Links
| GAP207/12/2323, research and development project |
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| GA13-26629S, research and development project |
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| MUNI/M/1894/2014, interní kód MU |
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