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@article{1355889, author = {Lénárt, Peter and Krejčí, Lumír}, article_location = {Amsterdam}, article_number = {"April"}, doi = {http://dx.doi.org/10.1016/j.mrfmmm.2016.01.007}, keywords = {DNA; Aging; Chromatin structure; Telomeres; DNA damage; DNA repair; Mutagenesis}, language = {eng}, issn = {0027-5107}, journal = {Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis}, title = {DNA, the central molecule of aging}, volume = {786}, year = {2016} }
TY - JOUR ID - 1355889 AU - Lénárt, Peter - Krejčí, Lumír PY - 2016 TI - DNA, the central molecule of aging JF - Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis VL - 786 IS - "April" SP - 1-7 EP - 1-7 PB - Elsevier Science BV SN - 00275107 KW - DNA KW - Aging KW - Chromatin structure KW - Telomeres KW - DNA damage KW - DNA repair KW - Mutagenesis N2 - Understanding the molecular mechanism of aging could have enormous medical implications. Despite a century of research, however, there is no universally accepted theory regarding the molecular basis of aging. On the other hand, there is plentiful evidence suggesting that DNA constitutes the central molecule in this process. Here, we review the roles of chromatin structure, DNA damage, and shortening of telomeres in aging and propose a hypothesis for how their interplay leads to aging phenotypes. ER -
LÉNÁRT, Peter and Lumír KREJČÍ. DNA, the central molecule of aging. \textit{Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis}. Amsterdam: Elsevier Science BV, 2016, vol.~786, ''April'', p.~1-7. ISSN~0027-5107. Available from: https://dx.doi.org/10.1016/j.mrfmmm.2016.01.007.
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