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@article{1355889,
author = {Lénárt, Peter and Krejčí, Lumír},
article_location = {Amsterdam},
article_number = {"April"},
doi = {http://dx.doi.org/10.1016/j.mrfmmm.2016.01.007},
keywords = {DNA; Aging; Chromatin structure; Telomeres; DNA damage; DNA repair; Mutagenesis},
language = {eng},
issn = {0027-5107},
journal = {Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis},
title = {DNA, the central molecule of aging},
volume = {786},
year = {2016}
}
TY - JOUR
ID - 1355889
AU - Lénárt, Peter - Krejčí, Lumír
PY - 2016
TI - DNA, the central molecule of aging
JF - Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis
VL - 786
IS - "April"
SP - 1-7
EP - 1-7
PB - Elsevier Science BV
SN - 00275107
KW - DNA
KW - Aging
KW - Chromatin structure
KW - Telomeres
KW - DNA damage
KW - DNA repair
KW - Mutagenesis
N2 - Understanding the molecular mechanism of aging could have enormous medical implications. Despite a century of research, however, there is no universally accepted theory regarding the molecular basis of aging. On the other hand, there is plentiful evidence suggesting that DNA constitutes the central molecule in this process. Here, we review the roles of chromatin structure, DNA damage, and shortening of telomeres in aging and propose a hypothesis for how their interplay leads to aging phenotypes.
ER -
LÉNÁRT, Peter and Lumír KREJČÍ. DNA, the central molecule of aging. \textit{Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis}. Amsterdam: Elsevier Science BV, vol.~786, ''April'', p.~1-7. ISSN~0027-5107. doi:10.1016/j.mrfmmm.2016.01.007. 2016.
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