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@article{1356671,
author = {Nguyen, Hoai Viet and Richtera, Lukas and Moulick, Amitava and Xhaxhiu, Kledi and Kudr, Jiri and Cernei, Natalia and Polanská, Hana and Heger, Zbynek and Masařík, Michal and Kopel, Pavel and Stiborova, Marie and Eckschlager, Tomas and Adam, Vojtech and Kizek, Rene},
article_location = {Cambridge},
article_number = {9},
doi = {http://dx.doi.org/10.1039/c5an02476e},
keywords = {PERFORMANCE LIQUID-CHROMATOGRAPHY; DNA TOPOISOMERASE-II; HUMAN PLASMA; CATECHOL METABOLITE; EMERGENT NANOLIGHTS; ANTITUMOR AGENTS; VP 16-213; NANOPARTICLES; DRUGS; CELLS},
language = {eng},
issn = {0003-2654},
journal = {Analyst},
title = {Electrochemical sensing of etoposide using carbon quantum dot modified glassy carbon electrode},
volume = {141},
year = {2016}
}
TY - JOUR
ID - 1356671
AU - Nguyen, Hoai Viet - Richtera, Lukas - Moulick, Amitava - Xhaxhiu, Kledi - Kudr, Jiri - Cernei, Natalia - Polanská, Hana - Heger, Zbynek - Masařík, Michal - Kopel, Pavel - Stiborova, Marie - Eckschlager, Tomas - Adam, Vojtech - Kizek, Rene
PY - 2016
TI - Electrochemical sensing of etoposide using carbon quantum dot modified glassy carbon electrode
JF - Analyst
VL - 141
IS - 9
SP - 2665-2675
EP - 2665-2675
PB - The Royal Society of Chemistry
SN - 00032654
KW - PERFORMANCE LIQUID-CHROMATOGRAPHY
KW - DNA TOPOISOMERASE-II
KW - HUMAN PLASMA
KW - CATECHOL METABOLITE
KW - EMERGENT NANOLIGHTS
KW - ANTITUMOR AGENTS
KW - VP 16-213
KW - NANOPARTICLES
KW - DRUGS
KW - CELLS
N2 - In this study, enhancement of the electrochemical signals of etoposide (ETO) measured by differential pulse voltammetry (DPV) by modifying a glassy carbon electrode (GCE) with carbon quantum dots (CQDs) is demonstrated. In comparison with a bare GCE, the modified GCE exhibited a higher sensitivity towards electrochemical detection of ETO. The lowest limit of detection was observed to be 5 nM ETO. Furthermore, scanning electron microscopy (SEM), fluorescence microscopy (FM), and electrochemical impedance spectroscopy (EIS) were employed for the further study of the working electrode surface after the modification with CQDs. Finally, the GCE modified with CQDs under optimized conditions was used to analyse real samples of ETO in the prostate cancer cell line PC3. After different incubation times (1, 3, 6, 9, 12, 18 and 24 h), these samples were then prepared prior to electrochemical detection by the GCE modified with CQDs. High performance liquid chromatography with an electrochemical detection method was employed to verify the results from the GCE modified with CQDs.
ER -
NGUYEN, Hoai Viet, Lukas RICHTERA, Amitava MOULICK, Kledi XHAXHIU, Jiri KUDR, Natalia CERNEI, Hana POLANSKÁ, Zbynek HEGER, Michal MASAŘÍK, Pavel KOPEL, Marie STIBOROVA, Tomas ECKSCHLAGER, Vojtech ADAM and Rene KIZEK. Electrochemical sensing of etoposide using carbon quantum dot modified glassy carbon electrode. \textit{Analyst}. Cambridge: The Royal Society of Chemistry, 2016, vol.~141, No~9, p.~2665-2675. ISSN~0003-2654. Available from: https://dx.doi.org/10.1039/c5an02476e.
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