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@article{1356689,
author = {Polanská, Hana and Heger, Zbynek and Gumulec, Jaromír and Raudenská, Martina and Svobodová, Markéta and Balvan, Jan and Fojtů, Michaela and Binková, Hana and Horáková, Zuzana and Kostřica, Rom and Adam, Vojtech and Kizek, Rene and Masařík, Michal},
article_location = {Dordrecht},
article_number = {6},
doi = {http://dx.doi.org/10.1007/s13277-015-4569-6},
keywords = {Head and neck cancer; Human papillomavirus; Tumor markers; Kaplan-Meier analysis},
language = {eng},
issn = {1010-4283},
journal = {Tumor Biology},
title = {Effect of HPV on tumor expression levels of the most commonly used markers in HNSCC},
volume = {37},
year = {2016}
}
TY - JOUR
ID - 1356689
AU - Polanská, Hana - Heger, Zbynek - Gumulec, Jaromír - Raudenská, Martina - Svobodová, Markéta - Balvan, Jan - Fojtů, Michaela - Binková, Hana - Horáková, Zuzana - Kostřica, Rom - Adam, Vojtech - Kizek, Rene - Masařík, Michal
PY - 2016
TI - Effect of HPV on tumor expression levels of the most commonly used markers in HNSCC
JF - Tumor Biology
VL - 37
IS - 6
SP - 7193-7201
EP - 7193-7201
PB - Springer
SN - 10104283
KW - Head and neck cancer
KW - Human papillomavirus
KW - Tumor markers
KW - Kaplan-Meier analysis
N2 - Approximately 90 % of head and neck cancers are squamous cell carcinomas (HNSCC), and the overall 5-year survival rate is not higher than 50 %. There is much evidence that human papillomavirus (HPV) infection may influence the expression of commonly studied HNSCC markers. Our study was focused on the possible HPV-specificity of molecular markers that could be key players in important steps of cancerogenesis (MKI67, EGF, EGFR, BCL-2, BAX, FOS, JUN, TP53, MT1A, MT2A, VEGFA, FLT1, MMP2, MMP9, and POU5F). qRT-PCR analysis of these selected genes was performed on 74 biopsy samples of tumors from patients with histologically verified HNSCC (22 HPV-, 52 HPV+). Kaplan-Meier analysis was done to determine the relevance of these selected markers for HNSCC prognosis. In conclusion, our study confirms the impact of HPV infection on commonly studied HNSCC markers MT2A, MMP9, FLT1, VEGFA, and POU5F that were more highly expressed in HPV-negative HNSCC patients and also shows the relevance of studied markers in HPV-positive and HPV-negative HNSCC patients.
ER -
POLANSKÁ, Hana, Zbynek HEGER, Jaromír GUMULEC, Martina RAUDENSKÁ, Markéta SVOBODOVÁ, Jan BALVAN, Michaela FOJTŮ, Hana BINKOVÁ, Zuzana HORÁKOVÁ, Rom KOSTŘICA, Vojtech ADAM, Rene KIZEK and Michal MASAŘÍK. Effect of HPV on tumor expression levels of the most commonly used markers in HNSCC. \textit{Tumor Biology}. Dordrecht: Springer, 2016, vol.~37, No~6, p.~7193-7201. ISSN~1010-4283. Available from: https://dx.doi.org/10.1007/s13277-015-4569-6.
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