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@article{1356774,
author = {Páchniková, Gabriela and Uldrijan, Stjepan and Imramovský, Aleš and Kryštof, Vladimír and Slaninová, Iva},
article_location = {Kidlington},
article_number = {"neuvedeno"},
doi = {http://dx.doi.org/10.1016/j.tiv.2016.09.006},
keywords = {Actin; Autophagy; Melanoma; Metabolic stress; Sorafenib; Substituted 2-hydroxy-N-(arylalkyl)benzamid},
language = {eng},
issn = {0887-2333},
journal = {Toxicology in Vitro},
title = {Substituted 2-hydroxy-N-(arylalkyl)benzamide sensitizes cancer cells to metabolic stress by disrupting actin cytoskeleton and inhibiting autophagic flux},
volume = {37},
year = {2016}
}
TY - JOUR
ID - 1356774
AU - Páchniková, Gabriela - Uldrijan, Stjepan - Imramovský, Aleš - Kryštof, Vladimír - Slaninová, Iva
PY - 2016
TI - Substituted 2-hydroxy-N-(arylalkyl)benzamide sensitizes cancer cells to metabolic stress by disrupting actin cytoskeleton and inhibiting autophagic flux
JF - Toxicology in Vitro
VL - 37
IS - "neuvedeno"
SP - 70-78
EP - 70-78
PB - Pergamon-Elsevier Science LTD
SN - 08872333
KW - Actin
KW - Autophagy
KW - Melanoma
KW - Metabolic stress
KW - Sorafenib
KW - Substituted 2-hydroxy-N-(arylalkyl)benzamid
N2 - N-((R)-1-(4-chlorophenylcarbamoyl)-2-phenylethyl)-5-chloro-2-hydroxybenzamide (Compound 6k), was recently isolated during the preparation of amino acids esters with salicylanilides. We show here that 6k disrupts the dynamics of actin cytoskeleton in human melanoma cells, affecting processes essential for the maintenance and expansion of tumours such as cell adhesion, motility, proliferation, vesicular transport, and autophagic flux. We demonstrated that inhibition of autophagy by 6k increased the sensitivity of melanoma cells to metabolic stress induced by rotenone or nutrient starvation and potentiated the anti-proliferative activity of small molecule multikinase inhibitor sorafenib. Since autophagy plays an important role in survival of cancer cells subjected to chemotherapy, the above mentioned properties are interesting from clinical point of view as 6k could promote metabolic stress within the tumour microenvironment and potentiate the effect of cytostatics in combination therapy.
ER -
PÁCHNIKOVÁ, Gabriela, Stjepan ULDRIJAN, Aleš IMRAMOVSKÝ, Vladimír KRYŠTOF and Iva SLANINOVÁ. Substituted 2-hydroxy-N-(arylalkyl)benzamide sensitizes cancer cells to metabolic stress by disrupting actin cytoskeleton and inhibiting autophagic flux. \textit{Toxicology in Vitro}. Kidlington: Pergamon-Elsevier Science LTD, 2016, vol.~37, ''neuvedeno'', p.~70-78. ISSN~0887-2333. Available from: https://dx.doi.org/10.1016/j.tiv.2016.09.006.
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