Treponema pallidum, the syphilis spirochete: making a living as
a stealth pathogen

J 2016

Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen

RADOLF, Justin D., Ranjit K. DEKA, Arvind ANAND, David ŠMAJS, Michael V. NORGARD et. al.

Basic information

Original name

Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen

Authors

RADOLF, Justin D. (840 United States of America), Ranjit K. DEKA (840 United States of America), Arvind ANAND (840 United States of America), David ŠMAJS (203 Czech Republic, guarantor, belonging to the institution), Michael V. NORGARD (840 United States of America) and X. Frank YANG (840 United States of America)

Edition

Nature Reviews Microbiology, London, Nature Publishing Group, 2016, 1740-1526

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 26.819

RIV identification code

RIV/00216224:14110/16:00088237

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1038/nrmicro.2016.141

UT WoS

000388217400008

Keywords in English

OUTER-MEMBRANE PROTEIN; PYROPHOSPHATE-DEPENDENT PHOSPHOFRUCTOKINASE; LYME-DISEASE SPIROCHETE; WHOLE GENOME SEQUENCE; BORRELIA-BURGDORFERI; SECONDARY SYPHILIS; PHOSPHOTRANSFERASE SYSTEM; BINDING PROTEIN; SUBSP PALLIDUM; ANTIGENIC VARIATION

Abstract

V originále

The past two decades have seen a worldwide resurgence in infections caused by Treponema pallidum subsp. pallidum, the syphilis spirochete. The well-recognized capacity of the syphilis spirochete for early dissemination and immune evasion has earned it the designation ‘the stealth pathogen’. Despite the many hurdles to studying syphilis pathogenesis, most notably the inability to culture and to genetically manipulate T. pallidum, in recent years, considerable progress has been made in elucidating the structural, physiological, and regulatory facets of T. pallidum pathogenicity. In this Review, we integrate this eclectic body of information to garner fresh insights into the highly successful parasitic lifestyles of the syphilis spirochete and related pathogenic treponemes.

Links

GAP302/12/0574, research and development project

Name: Celogenomové sekvencování v analýze genomů a transkriptomů patogenních bakterií rodu Treponema

Investor: Czech Science Foundation

NT11159, research and development project

Name: Mapování výskytu makrolidové rezistence původce syfilis v ČR a molekulární typizace jednotlivých syfilitických kmenů

Investor: Ministry of Health of the CR

Citovat

RADOLF, Justin D., Ranjit K. DEKA, Arvind ANAND, David ŠMAJS, Michael V. NORGARD and X. Frank YANG. Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen. Nature Reviews Microbiology. London: Nature Publishing Group, 2016, vol. 14, No 12, p. 744-759. ISSN 1740-1526. Available from: https://dx.doi.org/10.1038/nrmicro.2016.141.

@article{1356791,
   author = {Radolf, Justin D. and Deka, Ranjit K. and Anand, Arvind and Šmajs, David and Norgard, Michael V. and Yang, X. Frank},
   article_location = {London},
   article_number = {12},
   doi = {http://dx.doi.org/10.1038/nrmicro.2016.141},
   keywords = {OUTER-MEMBRANE PROTEIN; PYROPHOSPHATE-DEPENDENT PHOSPHOFRUCTOKINASE; LYME-DISEASE SPIROCHETE; WHOLE GENOME SEQUENCE; BORRELIA-BURGDORFERI; SECONDARY SYPHILIS; PHOSPHOTRANSFERASE SYSTEM; BINDING PROTEIN; SUBSP PALLIDUM; ANTIGENIC VARIATION},
   language = {eng},
   issn = {1740-1526},
   journal = {Nature Reviews Microbiology},
   title = {Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen},
   volume = {14},
   year = {2016}
}

TY  - JOUR
ID  - 1356791
AU  - Radolf, Justin D. - Deka, Ranjit K. - Anand, Arvind - Šmajs, David - Norgard, Michael V. - Yang, X. Frank
PY  - 2016
TI  - Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen
JF  - Nature Reviews Microbiology
VL  - 14
IS  - 12
SP  - 744-759
EP  - 744-759
PB  - Nature Publishing Group
SN  - 17401526
KW  - OUTER-MEMBRANE PROTEIN
KW  - PYROPHOSPHATE-DEPENDENT PHOSPHOFRUCTOKINASE
KW  - LYME-DISEASE SPIROCHETE
KW  - WHOLE GENOME SEQUENCE
KW  - BORRELIA-BURGDORFERI
KW  - SECONDARY SYPHILIS
KW  - PHOSPHOTRANSFERASE SYSTEM
KW  - BINDING PROTEIN
KW  - SUBSP PALLIDUM
KW  - ANTIGENIC VARIATION
N2  - The past two decades have seen a worldwide resurgence in infections caused by Treponema pallidum subsp. pallidum, the syphilis spirochete. The well-recognized capacity of the syphilis spirochete for early dissemination and immune evasion has earned it the designation ‘the stealth pathogen’. Despite the many hurdles to studying syphilis pathogenesis, most notably the inability to culture and to genetically manipulate T. pallidum, in recent years, considerable progress has been made in elucidating the structural, physiological, and regulatory facets of T. pallidum pathogenicity. In this Review, we integrate this eclectic body of information to garner fresh insights into the highly successful parasitic lifestyles of the syphilis spirochete and related pathogenic treponemes.
ER  -

RADOLF, Justin D., Ranjit K. DEKA, Arvind ANAND, David ŠMAJS, Michael V. NORGARD and X. Frank YANG. Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen. \textit{Nature Reviews Microbiology}. London: Nature Publishing Group, 2016, vol.~14, No~12, p.~744-759. ISSN~1740-1526. Available from: https://dx.doi.org/10.1038/nrmicro.2016.141.

Detailed Information on Publication Record