| RESSNEROVÁ, Alžběta, Martina RAUDENSKÁ, Monika HOLUBOVÁ, Markéta SVOBODOVÁ, Hana POLANSKÁ, Petr BABULA, Michal MASAŘÍK and Jaromír GUMULEC. Zinc and Copper Homeostasis in Head and Neck Cancer: Review and Meta-Analysis. Current Medicinal Chemistry. Sharjah: Betham Science Publishers, 2016, vol. 23, No 13, p. 1304-1330. ISSN 0929-8673. Available from: https://dx.doi.org/10.2174/0929867323666160405111543. |
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@article{1357221,
author = {Ressnerová, Alžběta and Raudenská, Martina and Holubová, Monika and Svobodová, Markéta and Polanská, Hana and Babula, Petr and Masařík, Michal and Gumulec, Jaromír},
article_location = {Sharjah},
article_number = {13},
doi = {http://dx.doi.org/10.2174/0929867323666160405111543},
keywords = {zinc; copper; ceruloplasmin; metallothionein; cancer; head and neck tumour; metallomics; meta-analysis},
language = {eng},
issn = {0929-8673},
journal = {Current Medicinal Chemistry},
title = {Zinc and Copper Homeostasis in Head and Neck Cancer: Review and Meta-Analysis},
volume = {23},
year = {2016}
}
TY - JOUR
ID - 1357221
AU - Ressnerová, Alžběta - Raudenská, Martina - Holubová, Monika - Svobodová, Markéta - Polanská, Hana - Babula, Petr - Masařík, Michal - Gumulec, Jaromír
PY - 2016
TI - Zinc and Copper Homeostasis in Head and Neck Cancer: Review and Meta-Analysis
JF - Current Medicinal Chemistry
VL - 23
IS - 13
SP - 1304-1330
EP - 1304-1330
PB - Betham Science Publishers
SN - 09298673
KW - zinc
KW - copper
KW - ceruloplasmin
KW - metallothionein
KW - cancer
KW - head and neck tumour
KW - metallomics
KW - meta-analysis
N2 - Metals are known for playing essential roles in human physiology. Copper and zinc are trace elements closely dependent on one another and are involved in cell proliferation, growth, gene expression, apoptosis and other processes. Their homeostasis is crucial and tightly controlled by a resourceful system of transporters and transport proteins which deliver copper and zinc ions to their target sites. Abnormal zinc and copper homeostasis can be seen in a number of malignancies and also in head and neck cancer. Imbalance in this homeostasis is observed as an elevation or decrease of copper and zinc ions in serum or tissue levels in patients with cancer. In head and neck cancer these altered levels stand out from those of other malignancies which makes them an object of interest and therefore zinc and copper ions might be a good target for further research of head and neck cancer development and progression. This review aims to summarize the physiological roles of copper and zinc, its binding and transport mechanisms, and based on those, its role in head and neck cancer. To provide stronger evidence, dysregulation of levels is analysed by a meta-analytical approach.
ER -
RESSNEROVÁ, Alžběta, Martina RAUDENSKÁ, Monika HOLUBOVÁ, Markéta SVOBODOVÁ, Hana POLANSKÁ, Petr BABULA, Michal MASAŘÍK and Jaromír GUMULEC. Zinc and Copper Homeostasis in Head and Neck Cancer: Review and Meta-Analysis. \textit{Current Medicinal Chemistry}. Sharjah: Betham Science Publishers, 2016, vol.~23, No~13, p.~1304-1330. ISSN~0929-8673. Available from: https://dx.doi.org/10.2174/0929867323666160405111543.
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