SHYAMSUNDER, Pavithra, Milan EŠNER, Maunish BARVALIA, Yu Jun WU, Tomáš LOJA, Huat Bay BOON, Matilde E. LLEONART, Rama S VERMA, Lumír KREJČÍ and Alex LYAKHOVICH. Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission. Oncotarget. New York: Impact Journals, 2016, vol. 7, No 36, p. 58065-58074. ISSN 1949-2553. Available from: https://dx.doi.org/10.18632/oncotarget.11161. |
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@article{1357230, author = {Shyamsunder, Pavithra and Ešner, Milan and Barvalia, Maunish and Wu, Yu Jun and Loja, Tomáš and Boon, Huat Bay and Lleonart, Matilde E. and Verma, Rama S and Krejčí, Lumír and Lyakhovich, Alex}, article_location = {New York}, article_number = {36}, doi = {http://dx.doi.org/10.18632/oncotarget.11161}, keywords = {mitophagy; impaired autophagy; Fanconi anemia; ROS; oxidative stress}, language = {eng}, issn = {1949-2553}, journal = {Oncotarget}, title = {Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission}, volume = {7}, year = {2016} }
TY - JOUR ID - 1357230 AU - Shyamsunder, Pavithra - Ešner, Milan - Barvalia, Maunish - Wu, Yu Jun - Loja, Tomáš - Boon, Huat Bay - Lleonart, Matilde E. - Verma, Rama S - Krejčí, Lumír - Lyakhovich, Alex PY - 2016 TI - Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission JF - Oncotarget VL - 7 IS - 36 SP - 58065-58074 EP - 58065-58074 PB - Impact Journals SN - 19492553 KW - mitophagy KW - impaired autophagy KW - Fanconi anemia KW - ROS KW - oxidative stress N2 - Fanconi anemia (FA) is a rare genetic disorder associated with bone-marrow failure, genome instability and cancer predisposition. Recently, we and others have demonstrated dysfunctional mitochondria with morphological alterations in FA cells accompanied by high reactive oxygen species (ROS) levels. Mitochondrial morphology is regulated by continuous fusion and fission events and the misbalance between these two is often accompanied by autophagy. Here, we provide evidence of impaired autophagy in FA. We demonstrate that FA cells have increased number of autophagic (presumably mitophagic) events and accumulate dysfunctional mitochondria due to an impaired ability to degrade them. Moreover, mitochondrial fission accompanied by oxidative stress (OS) is a prerequisite condition for mitophagy in FA and blocking this pathway may release autophagic machinery to clear dysfunctional mitochondria. ER -
SHYAMSUNDER, Pavithra, Milan EŠNER, Maunish BARVALIA, Yu Jun WU, Tomáš LOJA, Huat Bay BOON, Matilde E. LLEONART, Rama S VERMA, Lumír KREJČÍ and Alex LYAKHOVICH. Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission. \textit{Oncotarget}. New York: Impact Journals, 2016, vol.~7, No~36, p.~58065-58074. ISSN~1949-2553. Available from: https://dx.doi.org/10.18632/oncotarget.11161.
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