| SILVA, Sonia, Veronika ALTMANNOVÁ, Nadine ECKERT-BOULET, Peter KOLESÁR, Irene GALLINA, Lisa HANG, Inn CHUNG, Milica ARNERIC, Xiaolan ZHAO, Line Due BURON, Uffe H. MORTENSEN, Lumír KREJČÍ and Michael LISBY. SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination. DNA Repair. Amsterdam: Elsevier Science BV, 2016, vol. 42, "neuvedeno", p. 11-25. ISSN 1568-7864. Available from: https://dx.doi.org/10.1016/j.dnarep.2016.04.001. |
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@article{1357238,
author = {Silva, Sonia and Altmannová, Veronika and EckertandBoulet, Nadine and Kolesár, Peter and Gallina, Irene and Hang, Lisa and Chung, Inn and Arneric, Milica and Zhao, Xiaolan and Buron, Line Due and Mortensen, Uffe H. and Krejčí, Lumír and Lisby, Michael},
article_location = {Amsterdam},
article_number = {"neuvedeno"},
doi = {http://dx.doi.org/10.1016/j.dnarep.2016.04.001},
keywords = {Homologous recombination; Rad52; Rad59; Srs2; Rad51; SUMOylation},
language = {eng},
issn = {1568-7864},
journal = {DNA Repair},
title = {SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination},
volume = {42},
year = {2016}
}
TY - JOUR
ID - 1357238
AU - Silva, Sonia - Altmannová, Veronika - Eckert-Boulet, Nadine - Kolesár, Peter - Gallina, Irene - Hang, Lisa - Chung, Inn - Arneric, Milica - Zhao, Xiaolan - Buron, Line Due - Mortensen, Uffe H. - Krejčí, Lumír - Lisby, Michael
PY - 2016
TI - SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination
JF - DNA Repair
VL - 42
IS - "neuvedeno"
SP - 11-25
EP - 11-25
PB - Elsevier Science BV
SN - 15687864
KW - Homologous recombination
KW - Rad52
KW - Rad59
KW - Srs2
KW - Rad51
KW - SUMOylation
N2 - Homologous recombination (HR) is essential for maintenance of genome stability through double-strand break (DSB) repair, but at the same time HR can lead to loss of heterozygosity and uncontrolled recombination can be genotoxic. The post-translational modification by SUMO (small ubiquitin-like modifier) has been shown to modulate recombination, but the exact mechanism of this regulation remains unclear. Here we show that SUMOylation stabilizes the interaction between the recombination mediator Rad52 and its paralogue Rad59 in Saccharomyces cerevisiae. Although Rad59 SUMOylation is not required for survival after genotoxic stress, it affects the outcome of recombination to promote conservative DNA repair. In some genetic assays, Rad52 and Rad59 SUMOylation act synergistically. Collectively, our data indicate that the described SUMO modifications affect the balance between conservative and non-conservative mechanisms of HR. (C) 2016 Elsevier B.V. All rights reserved.
ER -
SILVA, Sonia, Veronika ALTMANNOVÁ, Nadine ECKERT-BOULET, Peter KOLESÁR, Irene GALLINA, Lisa HANG, Inn CHUNG, Milica ARNERIC, Xiaolan ZHAO, Line Due BURON, Uffe H. MORTENSEN, Lumír KREJČÍ and Michael LISBY. SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination. \textit{DNA Repair}. Amsterdam: Elsevier Science BV, 2016, vol.~42, ''neuvedeno'', p.~11-25. ISSN~1568-7864. Available from: https://dx.doi.org/10.1016/j.dnarep.2016.04.001.
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