IZAKOVIČOVÁ HOLLÁ, Lydie, Petra BOŘILOVÁ LINHARTOVÁ, Jakub KAŠTOVSKÝ, Michaela BARTOŠOVÁ, Kristína MUSILOVÁ, Lubomír KUKLA and Martina KUKLETOVÁ. Vitamin D receptor TaqI gene polymorphism and dental caries in Czech children. Caries Research. Basel: Karger, 2017, vol. 51, No 1, p. 7-11. ISSN 0008-6568. Available from: https://dx.doi.org/10.1159/000452635.
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Basic information
Original name Vitamin D receptor TaqI gene polymorphism and dental caries in Czech children
Name in Czech TaqI polymorfizmus v genu pro receptor vitaminu D a zubní kaz u českých dětí
Authors IZAKOVIČOVÁ HOLLÁ, Lydie (203 Czech Republic, guarantor, belonging to the institution), Petra BOŘILOVÁ LINHARTOVÁ (203 Czech Republic, belonging to the institution), Jakub KAŠTOVSKÝ (203 Czech Republic, belonging to the institution), Michaela BARTOŠOVÁ (703 Slovakia, belonging to the institution), Kristína MUSILOVÁ (203 Czech Republic), Lubomír KUKLA (203 Czech Republic, belonging to the institution) and Martina KUKLETOVÁ (203 Czech Republic).
Edition Caries Research, Basel, Karger, 2017, 0008-6568.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30208 Dentistry, oral surgery and medicine
Country of publisher Switzerland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.188
RIV identification code RIV/00216224:14110/17:00094561
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1159/000452635
UT WoS 000395969500003
Keywords in English case-control study; dental caries; gene polymorphism; Gingivitis; Vitamin D receptor
Tags EL OK, podil
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 18/3/2018 15:34.
Abstract
Aim: We analyzed the VDR TaqI (rs731236) gene polymorphism in children with and those without dental caries. Methods: A total of 388 subjects, 153 caries-free (with decayed/missing/filled teeth [DMFT] = 0) and 235 children with dental caries (DMFT >=1), were genotyped by the TaqMan method. Results: Although no significant differences in VDR TaqI allele and genotype frequencies between caries-free and caries-affected children were detected, a significant association between this polymorphism and gingivitis was found (p < 0.05). Conclusions: In contrast to previous studies from China and Turkey, the VDR TaqI gene variant cannot be used as a marker for identification of Czech children with increased dental caries risk.
Abstract (in Czech)
V práci jsme analyzovali TaqI (rs731236) polymorfizmus v genu pro VDR. Na rozdíl od dřívějších studií z Číny a Turecka, VDR TaqI varianta genu nemůže být využita jako "marker" zvýšeného rizika zubního kazu u českých dětí.
Links
GB14-37368G, research and development projectName: Centrum orofaciálního vývoje a regenerace
Investor: Czech Science Foundation
MUNI/A/1258/2015, interní kód MUName: Analýza klinických, mikrobiálních a genetických faktorů v etiopatogenezi vybraných patologických stavů v dutině ústní
Investor: Masaryk University, Category A
ROZV/24/LF/2016, interní kód MUName: LF - Příspěvek IP 2016
Investor: Ministry of Education, Youth and Sports of the CR
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