J 2016

Trace Element Status (Zinc, Copper, Selenium, Iron, Manganese) in Patients with Long-Term Home Parenteral Nutrition

DASTYCH, Milan, Michal ŠENKYŘÍK, Milan DASTYCH, František NOVÁK, Petr WOHL et. al.

Basic information

Original name

Trace Element Status (Zinc, Copper, Selenium, Iron, Manganese) in Patients with Long-Term Home Parenteral Nutrition

Authors

DASTYCH, Milan (203 Czech Republic, guarantor, belonging to the institution), Michal ŠENKYŘÍK (203 Czech Republic, belonging to the institution), Milan DASTYCH (203 Czech Republic, belonging to the institution), František NOVÁK (203 Czech Republic), Petr WOHL (203 Czech Republic), Jan MAŇÁK (203 Czech Republic) and Pavel KOHOUT (203 Czech Republic)

Edition

Annals of Nutrition and Metabolism, Basel, Karger, 2016, 0250-6807

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30304 Public and environmental health

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.424

RIV identification code

RIV/00216224:14110/16:00091459

Organization unit

Faculty of Medicine

DOI

UT WoS

000388417300055

Keywords in English

Home parenteral nutrition; Short bowel syndrome; Trace elements

Tags

Tags

International impact, Reviewed
Změněno: 6/1/2017 13:25, Ing. Mgr. Věra Pospíšilíková

Abstract

V originále

Background: The objective of the present study was to determine concentrations of zinc (Zn), copper (Cu), iron (Fe), selenium (Se) in blood plasma and manganese (Mn) in the whole blood in patients with long-term home parenteral nutrition (HPN) in comparison to the control group. Patients and Methods: We examined 68 patients (16 men and 52 women) aged from 28 to 68 years on a long-term HPN lasting from 4 to 96 months. The short bowel syndrome was an indication for HPN. The daily doses of Zn, Cu, Fe, Se and Mn in the last 3 months were determined. Results: No significant differences in blood plasma were found for Zn, Cu and Fe in patients with HPN and in the control group (p > 0.05). The concentration of Mn in whole blood was significantly increased in HPN patients (p < 0.0001), while Se concentration in these patients was significantly decreased (p < 0.005). The concentration of Mn in the whole blood of 16 patients with cholestasis was significantly increased compared to the patients without cholestasis (p < 0.001). The Cu concentration was increased with no statistical significance. Conclusion: In long-term HPN, the status of trace elements in the patients has to be continually monitored and the daily substitution doses of these elements have to be flexibly adjusted. Dosing schedule needs to be adjusted especially in cases of cholestatic hepatopathy. A discussion about the optimal daily dose of Mn in patients on HPN is appropriate. For clinical practice, the availability of a substitution mixture of trace elements lacking Mn would be advantageous.