Intestinal sulfate-reducing bacteria under the effect of
salicylamides derivatives

D 2016

Intestinal sulfate-reducing bacteria under the effect of salicylamides derivatives

KUSHKEVYCH, Ivan, Monika VÍTĚZOVÁ, Peter KOLLAR and Josef JAMPILEK

Basic information

Original name

Intestinal sulfate-reducing bacteria under the effect of salicylamides derivatives

Authors

KUSHKEVYCH, Ivan (804 Ukraine, belonging to the institution), Monika VÍTĚZOVÁ (203 Czech Republic, belonging to the institution), Peter KOLLAR (203 Czech Republic) and Josef JAMPILEK (203 Czech Republic)

Edition

Ivan Franko Lviv National Un. Lviv, Achievements and prospects of microbiology, p. 72-74, 3 pp. 2016

Publisher

Ivan Franko Lviv National University

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

10600 1.6 Biological sciences

Country of publisher

Ukraine

Confidentiality degree

není předmětem státního či obchodního tajemství

Publication form

printed version "print"

RIV identification code

RIV/00216224:14310/16:00095905

Organization unit

Faculty of Science

ISBN

978-966-919-203-5

Keywords in English

salicylamides; bowel diseases; ulcerative colitis; sulfate-reducing bacteria

Abstract

V originále

Sulfate-reducing bacteria (SRB) are most likely involved in both the initiation and maintenance of the inflammatory bowel disease (IBD), unfortunately present antibacterial chemotherapeutics used in the treatment of IBD have been ineffective. Thus, the antimicrobial activity of salicylamide derivatives on two different genera of intestinal SRB, Desulfovibrio and Desulfomicrobium was investigated. Six 2-(phenylcarbamoyl)phenyl N-[(benzyloxy)carbonyl]alkanoatesand three 2-hydroxy-N-[(2S)-1-oxo-1-(phenylamino)alkan-2-yl]benzamides showed MIC values in the range from 0.22 to 0.35 microM against Desulfovibrio piger Vib-7 and in the range from 0.27 to 8.52 microM against Desulfomicrobium sp. Rod-9, which is by two orders of magnitude lower compared with ciprofloxacin.

Citovat

KUSHKEVYCH, Ivan, Monika VÍTĚZOVÁ, Peter KOLLAR and Josef JAMPILEK. Intestinal sulfate-reducing bacteria under the effect of salicylamides derivatives. In Achievements and prospects of microbiology. Ivan Franko Lviv National Un. Lviv: Ivan Franko Lviv National University, 2016, p. 72-74. ISBN 978-966-919-203-5.

@inproceedings{1359523,
   author = {Kushkevych, Ivan and Vítězová, Monika and Kollar, Peter and Jampilek, Josef},
   address = {Lviv},
   booktitle = {Achievements and prospects of microbiology},
   edition = {Ivan Franko Lviv National Un},
   keywords = {salicylamides; bowel diseases; ulcerative colitis; sulfate-reducing bacteria},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {Lviv},
   isbn = {978-966-919-203-5},
   pages = {72-74},
   publisher = {Ivan Franko Lviv National University},
   title = {Intestinal sulfate-reducing bacteria under the effect of salicylamides derivatives},
   year = {2016}
}

TY  - JOUR
ID  - 1359523
AU  - Kushkevych, Ivan - Vítězová, Monika - Kollar, Peter - Jampilek, Josef
PY  - 2016
TI  - Intestinal sulfate-reducing bacteria under the effect of salicylamides derivatives
PB  - Ivan Franko Lviv National University
CY  - Lviv
SN  - 9789669192035
KW  - salicylamides
KW  - bowel diseases
KW  - ulcerative colitis
KW  - sulfate-reducing bacteria
N2  - Sulfate-reducing bacteria (SRB) are most likely involved in both the initiation and maintenance of the inflammatory bowel disease (IBD), unfortunately present antibacterial chemotherapeutics used in the treatment of IBD have been ineffective. Thus, the antimicrobial activity of salicylamide derivatives on two different genera of intestinal SRB, Desulfovibrio and Desulfomicrobium was investigated. Six 2-(phenylcarbamoyl)phenyl N-[(benzyloxy)carbonyl]alkanoatesand three 2-hydroxy-N-[(2S)-1-oxo-1-(phenylamino)alkan-2-yl]benzamides showed MIC values in the range from 0.22 to 0.35 microM against Desulfovibrio piger Vib-7 and in the range from 0.27 to 8.52 microM against Desulfomicrobium sp. Rod-9, which is by two orders of magnitude lower compared with ciprofloxacin.
ER  -

KUSHKEVYCH, Ivan, Monika VÍTĚZOVÁ, Peter KOLLAR and Josef JAMPILEK. Intestinal sulfate-reducing bacteria under the effect of salicylamides derivatives. In \textit{Achievements and prospects of microbiology}. Ivan Franko Lviv National Un. Lviv: Ivan Franko Lviv National University, 2016, p.~72-74. ISBN~978-966-919-203-5.

Detailed Information on Publication Record