CenH3 evolution reflects meiotic symmetry as predicted by the
centromere drive model

J 2016

CenH3 evolution reflects meiotic symmetry as predicted by the centromere drive model

ZEDEK, František and Petr BUREŠ

Basic information

Original name

CenH3 evolution reflects meiotic symmetry as predicted by the centromere drive model

Authors

ZEDEK, František (203 Czech Republic, belonging to the institution) and Petr BUREŠ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Scientific Reports, LONDON, NATURE PUBLISHING GROUP, 2016, 2045-2322

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10611 Plant sciences, botany

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.259

RIV identification code

RIV/00216224:14310/16:00088363

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1038/srep33308

UT WoS

000383188000001

Keywords in English

centromere drive; centromere; chromosomes; meiotic drive; CenH3; CENP-A; chromosomal evolution; karyotype; meiotic symmetry; meiotic asymmetry; holokinetic chromosomes

Abstract

V originále

The centromere drive model explaining rapid evolution of eukaryotic centromeres predicts higher frequency of positive selection acting on centromeric histone H3 (CenH3) in clades with asymmetric meiosis compared to the clades with only symmetric meiosis. However, despite the impression one might get from the literature, this key prediction of the centromere drive model has not only never been confirmed, but it has never been tested, because all the previous studies dealt only with the presence or absence instead of the frequency of positive selection. To provide evidence for or against different frequencies of positively selected CenH3 in asymmetrics and symmetrics, we have inferred the selective pressures acting on CenH3 in seventeen eukaryotic clades, including plants, animals, fungi, ciliates and apicomplexa, using codon-substitution models, and compared the inferred frequencies between asymmetrics and symmetrics in a quantitative manner. We have found that CenH3 has been evolving adaptively much more frequently in clades with asymmetric meiosis compared with clades displaying only symmetric meiosis which confirms the prediction of centromere drive model. Our findings indicate that the evolution of asymmetric meiosis required CenH3 to evolve adaptively more often to counterbalance the negative consequences of centromere drive.

Links

GA13-29362S, research and development project

Name: Evoluce holocentrických chromosomů (Acronym: EvoHolo)

Investor: Czech Science Foundation

Citovat

ZEDEK, František and Petr BUREŠ. CenH3 evolution reflects meiotic symmetry as predicted by the centromere drive model. Scientific Reports. LONDON: NATURE PUBLISHING GROUP, 2016, vol. 6, September, p. "nestrankovano", 6 pp. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/srep33308.

@article{1361213,
   author = {Zedek, František and Bureš, Petr},
   article_location = {LONDON},
   article_number = {September},
   doi = {http://dx.doi.org/10.1038/srep33308},
   keywords = {centromere drive; centromere; chromosomes; meiotic drive; CenH3; CENP-A; chromosomal evolution; karyotype; meiotic symmetry; meiotic asymmetry; holokinetic chromosomes},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {CenH3 evolution reflects meiotic symmetry as predicted by the centromere drive model},
   url = {http://www.nature.com/articles/srep33308},
   volume = {6},
   year = {2016}
}

TY  - JOUR
ID  - 1361213
AU  - Zedek, František - Bureš, Petr
PY  - 2016
TI  - CenH3 evolution reflects meiotic symmetry as predicted by the centromere drive model
JF  - Scientific Reports
VL  - 6
IS  - September
SP  - "nestrankovano"
EP  - "nestrankovano"
PB  - NATURE PUBLISHING GROUP
SN  - 20452322
KW  - centromere drive
KW  - centromere
KW  - chromosomes
KW  - meiotic drive
KW  - CenH3
KW  - CENP-A
KW  - chromosomal evolution
KW  - karyotype
KW  - meiotic symmetry
KW  - meiotic asymmetry
KW  - holokinetic chromosomes
UR  - http://www.nature.com/articles/srep33308
N2  - The centromere drive model explaining rapid evolution of eukaryotic centromeres predicts higher frequency of positive selection acting on centromeric histone H3 (CenH3) in clades with asymmetric meiosis compared to the clades with only symmetric meiosis. However, despite the impression one might get from the literature, this key prediction of the centromere drive model has not only never been confirmed, but it has never been tested, because all the previous studies dealt only with the presence or absence instead of the frequency of positive selection. To provide evidence for or against different frequencies of positively selected CenH3 in asymmetrics and symmetrics, we have inferred the selective pressures acting on CenH3 in seventeen eukaryotic clades, including plants, animals, fungi, ciliates and apicomplexa, using codon-substitution models, and compared the inferred frequencies between asymmetrics and symmetrics in a quantitative manner. We have found that CenH3 has been evolving adaptively much more frequently in clades with asymmetric meiosis compared with clades displaying only symmetric meiosis which confirms the prediction of centromere drive model. Our findings indicate that the evolution of asymmetric meiosis required CenH3 to evolve adaptively more often to counterbalance the negative consequences of centromere drive.
ER  -

ZEDEK, František and Petr BUREŠ. CenH3 evolution reflects meiotic symmetry as predicted by the centromere drive model. \textit{Scientific Reports}. LONDON: NATURE PUBLISHING GROUP, 2016, vol.~6, September, p.~''nestrankovano'', 6 pp. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/srep33308.

Detailed Information on Publication Record