Malignant catatonia due to anti-NMDA-receptor encephalitis in a
15-year-old girl: case report and summary of current knowledge

J 2016

Malignant catatonia due to anti-NMDA-receptor encephalitis in a 15-year-old girl: case report and summary of current knowledge

AULICKÁ, Štefánia, Ondřej HORÁK, Lenka MRÁZOVÁ, Peter MIKOLÁŠEK, Jaroslav ŠTĚRBA et. al.

Basic information

Original name

Malignant catatonia due to anti-NMDA-receptor encephalitis in a 15-year-old girl: case report and summary of current knowledge

Authors

AULICKÁ, Štefánia (703 Slovakia, guarantor, belonging to the institution), Ondřej HORÁK (203 Czech Republic, belonging to the institution), Lenka MRÁZOVÁ (203 Czech Republic, belonging to the institution), Peter MIKOLÁŠEK (703 Slovakia, belonging to the institution), Jaroslav ŠTĚRBA (203 Czech Republic), Lenka KRBKOVÁ (203 Czech Republic, belonging to the institution) and Hana OŠLEJŠKOVÁ (203 Czech Republic, belonging to the institution)

Edition

Neuropsychiatry, London, Future Medicine Ltd. 2016, 1758-2008

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 4.778

RIV identification code

RIV/00216224:14110/16:00091888

Organization unit

Faculty of Medicine

Keywords in English

NMDA receptor antibodies; malignant catatonia; paraneoplastic form; non-paraneoplastic form; immunotherapy

Abstract

V originále

Anti-N-methyl-D-aspartate receptor encephalitis is a recently identified autoimmune disorder with a prominent neuropsychiatric presentation. We present the case of a 15-yearold girl with partial complex seizures with secondary generalization and acute mania with psychotic features. A positive diagnosis of anti-NMDA-receptor encephalitis suggested the specific treatment. Despite first-line immune treatment, the patient progressed to stupor, malignant catatonia, and autonomic instability with the risk of cardiopulmonary function failure. She improved after second-line immunosuppressive therapy (cyclophosphamide and rituximab simultaneously). Post-cognitive sequelae (memory impairment and deliberation) disappeared within 8 months of follow-up treatment and intensive cognitive rehabilitation. This case report emphasizes the importance of differential diagnosis and adequate treatment of catatonic syndrome, especially in young adults. Early recognition and adequate treatment is essential for a good outcome for the patients.

Links

ROZV/24/LF/2016, interní kód MU

Name: LF - Příspěvek IP 2016

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

AULICKÁ, Štefánia, Ondřej HORÁK, Lenka MRÁZOVÁ, Peter MIKOLÁŠEK, Jaroslav ŠTĚRBA, Lenka KRBKOVÁ and Hana OŠLEJŠKOVÁ. Malignant catatonia due to anti-NMDA-receptor encephalitis in a 15-year-old girl: case report and summary of current knowledge. Neuropsychiatry. London: Future Medicine Ltd., 2016, vol. 6, No 4, p. 136-141. ISSN 1758-2008.

@article{1361661,
   author = {Aulická, Štefánia and Horák, Ondřej and Mrázová, Lenka and Mikolášek, Peter and Štěrba, Jaroslav and Krbková, Lenka and Ošlejšková, Hana},
   article_location = {London},
   article_number = {4},
   keywords = {NMDA receptor antibodies; malignant catatonia; paraneoplastic form; non-paraneoplastic form; immunotherapy},
   language = {eng},
   issn = {1758-2008},
   journal = {Neuropsychiatry},
   title = {Malignant catatonia due to anti-NMDA-receptor encephalitis in a 15-year-old girl: case report and summary of current knowledge},
   volume = {6},
   year = {2016}
}

TY  - JOUR
ID  - 1361661
AU  - Aulická, Štefánia - Horák, Ondřej - Mrázová, Lenka - Mikolášek, Peter - Štěrba, Jaroslav - Krbková, Lenka - Ošlejšková, Hana
PY  - 2016
TI  - Malignant catatonia due to anti-NMDA-receptor encephalitis in a 15-year-old girl: case report and summary of current knowledge
JF  - Neuropsychiatry
VL  - 6
IS  - 4
SP  - 136-141
EP  - 136-141
PB  - Future Medicine Ltd.
SN  - 17582008
KW  - NMDA receptor antibodies
KW  - malignant catatonia
KW  - paraneoplastic form
KW  - non-paraneoplastic form
KW  - immunotherapy
N2  - Anti-N-methyl-D-aspartate receptor encephalitis is a recently identified autoimmune disorder with a prominent neuropsychiatric presentation. We present the case of a 15-yearold girl with partial complex seizures with secondary generalization and acute mania with psychotic features. A positive diagnosis of anti-NMDA-receptor encephalitis suggested the specific treatment. Despite first-line immune treatment, the patient progressed to stupor, malignant catatonia, and autonomic instability with the risk of cardiopulmonary function failure. She improved after second-line immunosuppressive therapy (cyclophosphamide and rituximab simultaneously). Post-cognitive sequelae (memory impairment and deliberation) disappeared within 8 months of follow-up treatment and intensive cognitive rehabilitation. This case report emphasizes the importance of differential diagnosis and adequate treatment of catatonic syndrome, especially in young adults. Early recognition and adequate treatment is essential for a good outcome for the patients.
ER  -

AULICKÁ, Štefánia, Ondřej HORÁK, Lenka MRÁZOVÁ, Peter MIKOLÁŠEK, Jaroslav ŠTĚRBA, Lenka KRBKOVÁ and Hana OŠLEJŠKOVÁ. Malignant catatonia due to anti-NMDA-receptor encephalitis in a 15-year-old girl: case report and summary of current knowledge. \textit{Neuropsychiatry}. London: Future Medicine Ltd., 2016, vol.~6, No~4, p.~136-141. ISSN~1758-2008.

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