ŠTOURAČ, Petr. Remifentanil in Real Clinical Conditions: Strange Case of Dr. Jekyll and Mr. Hyde? Current medical research and opinion. Oxon: Taylor & Francis, 2016, vol. 32, No 12, p. 1983-1984. ISSN 0300-7995. Available from: https://dx.doi.org/10.1080/03007995.2016.1226164.
Other formats:   BibTeX LaTeX RIS
Basic information
Original name Remifentanil in Real Clinical Conditions: Strange Case of Dr. Jekyll and Mr. Hyde?
Name in Czech Remifentanil v reálných klinických podmínkách: Podivuhodný příběh dr. Jekylla a Mr. Hydea?
Name (in English) Remifentanil in Real Clinical Conditions: Strange Case of Dr. Jekyll and Mr. Hyde?
Authors ŠTOURAČ, Petr.
Edition Current medical research and opinion, Oxon, Taylor & Francis, 2016, 0300-7995.
Other information
Original language Czech
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 2.757
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1080/03007995.2016.1226164
UT WoS 000388960800010
Keywords (in Czech) remifentanil; porodní analgezie: opioidy navozená hyperalgezie
Keywords in English remifentnail; obstetric analgesia; opioid-induced hyperalgesia
Tags EL OK
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 27/1/2017 09:59.
Abstract
It appears that, like Dr. Jekyll and Mr. Hyde in the famous story by Robert Louis Stevenson, remifentanil in real clinical settings has two faces. While it is undoubtedly a potent and well controllable opioid agonist with unique pharmacokinetics and wide clinical application, on the other hand, perhaps no other opioid is as much associated with opioid-induced hyperalgesia (OIH), that is, initial analgesic effects that are followed by increased sensitivity to pain/reduced pain thresholds. Given the methodological variability of published studies, there is a need for more research including the contribution of remifentanil induced hyperalgesia to chronic pain and the role of pharmacological modulation to reverse this process. But the real clinically preferred examples of remifentanil use imply that the adverse effects can be maintained under control and therefore remifentanil does not have to follow the tragic fate of Stevenson’s story in the future.
Abstract (in English)
It appears that, like Dr. Jekyll and Mr. Hyde in the famous story by Robert Louis Stevenson, remifentanil in real clinical settings has two faces. While it is undoubtedly a potent and well controllable opioid agonist with unique pharmacokinetics and wide clinical application, on the other hand, perhaps no other opioid is as much associated with opioid-induced hyperalgesia (OIH), that is, initial analgesic effects that are followed by increased sensitivity to pain/reduced pain thresholds. Given the methodological variability of published studies, there is a need for more research including the contribution of remifentanil induced hyperalgesia to chronic pain and the role of pharmacological modulation to reverse this process. But the real clinically preferred examples of remifentanil use imply that the adverse effects can be maintained under control and therefore remifentanil does not have to follow the tragic fate of Stevenson’s story in the future.
PrintDisplayed: 12/10/2024 05:44