Detailed Information on Publication Record
2016
Bone marrow metastasis of malignant melanoma in childhood arising within a congenital melanocytic nevus
VOLEJNIKOVA, Jana, Viera BAJČIOVÁ, Lucie SULOVSKA, Marie GEIEROVA, Eva BURIANKOVA et. al.Basic information
Original name
Bone marrow metastasis of malignant melanoma in childhood arising within a congenital melanocytic nevus
Name (in English)
Bone marrow metastasis of malignant melanoma in childhood arising within a congenital melanocytic nevus
Authors
VOLEJNIKOVA, Jana (203 Czech Republic), Viera BAJČIOVÁ (703 Slovakia, belonging to the institution), Lucie SULOVSKA (203 Czech Republic), Marie GEIEROVA (203 Czech Republic), Eva BURIANKOVA (203 Czech Republic), Marie JAROSOVA (203 Czech Republic), Marian HAJDUCH (203 Czech Republic), Jaroslav ŠTĚRBA (203 Czech Republic, guarantor, belonging to the institution) and Vladimir MIHAL (203 Czech Republic)
Edition
Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc, Palacký University, 2016, 1213-8118
Other information
Language
Czech
Type of outcome
Článek v odborném periodiku
Field of Study
30200 3.2 Clinical medicine
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 0.894
RIV identification code
RIV/00216224:14110/16:00092091
Organization unit
Faculty of Medicine
UT WoS
000392808100019
Keywords in English
Bone marrow; Childhood; Congenital melanocytic nevus; Malignant melanoma; Metastasis
Tags
Tags
International impact, Reviewed
Změněno: 4/4/2017 13:25, Soňa Böhmová
V originále
Background. Malignant melanoma in childhood is infrequent and can arise within congenital melanocytic nevi. Spread of malignant melanoma to the bone marrow, especially in children, is extremely rare. Methods and Results. Reported is a case of a 5-year-old boy with a congenital large melanocytic nevus of the head and neck who presented with a short history of low back and leg pain, fever and cervical lymphadenopathy. Despite regular follow-up by a dermatologist and plastic surgeon and repeatedly negative histology of previous partial excisions, diffuse bone marrow infiltration with malignant melanoma was diagnosed. The primary site was identified in the post-excision area. The disease progressed rapidly on ipilimumab immunotherapy and led to death at four months from the diagnosis. Conclusion. Surveillance is indispensable in children with a predisposition to melanoma and nonspecific symptoms such as bone pain, gait impairment or cytopenia, should always be taken into account.
In English
Background. Malignant melanoma in childhood is infrequent and can arise within congenital melanocytic nevi. Spread of malignant melanoma to the bone marrow, especially in children, is extremely rare. Methods and Results. Reported is a case of a 5-year-old boy with a congenital large melanocytic nevus of the head and neck who presented with a short history of low back and leg pain, fever and cervical lymphadenopathy. Despite regular follow-up by a dermatologist and plastic surgeon and repeatedly negative histology of previous partial excisions, diffuse bone marrow infiltration with malignant melanoma was diagnosed. The primary site was identified in the post-excision area. The disease progressed rapidly on ipilimumab immunotherapy and led to death at four months from the diagnosis. Conclusion. Surveillance is indispensable in children with a predisposition to melanoma and nonspecific symptoms such as bone pain, gait impairment or cytopenia, should always be taken into account.