VOLEJNIKOVA, Jana, Viera BAJČIOVÁ, Lucie SULOVSKA, Marie GEIEROVA, Eva BURIANKOVA, Marie JAROSOVA, Marian HAJDUCH, Jaroslav ŠTĚRBA and Vladimir MIHAL. Bone marrow metastasis of malignant melanoma in childhood arising within a congenital melanocytic nevus. Biomedical Papers of the Faculty of Medicine of Palacký University. Olomouc: Palacký University, 2016, vol. 160, No 3, p. 456-460. ISSN 1213-8118. Available from: https://dx.doi.org/10.5507/bp.2016.018.
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Basic information
Original name Bone marrow metastasis of malignant melanoma in childhood arising within a congenital melanocytic nevus
Name (in English) Bone marrow metastasis of malignant melanoma in childhood arising within a congenital melanocytic nevus
Authors VOLEJNIKOVA, Jana (203 Czech Republic), Viera BAJČIOVÁ (703 Slovakia, belonging to the institution), Lucie SULOVSKA (203 Czech Republic), Marie GEIEROVA (203 Czech Republic), Eva BURIANKOVA (203 Czech Republic), Marie JAROSOVA (203 Czech Republic), Marian HAJDUCH (203 Czech Republic), Jaroslav ŠTĚRBA (203 Czech Republic, guarantor, belonging to the institution) and Vladimir MIHAL (203 Czech Republic).
Edition Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc, Palacký University, 2016, 1213-8118.
Other information
Original language Czech
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 0.894
RIV identification code RIV/00216224:14110/16:00092091
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.5507/bp.2016.018
UT WoS 000392808100019
Keywords in English Bone marrow; Childhood; Congenital melanocytic nevus; Malignant melanoma; Metastasis
Tags EL OK
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 4/4/2017 13:25.
Abstract
Background. Malignant melanoma in childhood is infrequent and can arise within congenital melanocytic nevi. Spread of malignant melanoma to the bone marrow, especially in children, is extremely rare. Methods and Results. Reported is a case of a 5-year-old boy with a congenital large melanocytic nevus of the head and neck who presented with a short history of low back and leg pain, fever and cervical lymphadenopathy. Despite regular follow-up by a dermatologist and plastic surgeon and repeatedly negative histology of previous partial excisions, diffuse bone marrow infiltration with malignant melanoma was diagnosed. The primary site was identified in the post-excision area. The disease progressed rapidly on ipilimumab immunotherapy and led to death at four months from the diagnosis. Conclusion. Surveillance is indispensable in children with a predisposition to melanoma and nonspecific symptoms such as bone pain, gait impairment or cytopenia, should always be taken into account.
Abstract (in English)
Background. Malignant melanoma in childhood is infrequent and can arise within congenital melanocytic nevi. Spread of malignant melanoma to the bone marrow, especially in children, is extremely rare. Methods and Results. Reported is a case of a 5-year-old boy with a congenital large melanocytic nevus of the head and neck who presented with a short history of low back and leg pain, fever and cervical lymphadenopathy. Despite regular follow-up by a dermatologist and plastic surgeon and repeatedly negative histology of previous partial excisions, diffuse bone marrow infiltration with malignant melanoma was diagnosed. The primary site was identified in the post-excision area. The disease progressed rapidly on ipilimumab immunotherapy and led to death at four months from the diagnosis. Conclusion. Surveillance is indispensable in children with a predisposition to melanoma and nonspecific symptoms such as bone pain, gait impairment or cytopenia, should always be taken into account.
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