| KOLEDOVÁ, Zuzana, Xiaohong ZHANG, Charles STREULI, Robert B. CLARKE, Ophir D. KLEIN, Zena WERB and Pengfei LU. SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling. Proceedings of the National Academy of Sciences of the United States of America. Washington: National Academy of Sciences, 2016, vol. 113, No 39, p. "E5731"-"E5740", 10 pp. ISSN 0027-8424. Available from: https://dx.doi.org/10.1073/pnas.1611532113. |
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@article{1363696,
author = {Koledová, Zuzana and Zhang, Xiaohong and Streuli, Charles and Clarke, Robert B. and Klein, Ophir D. and Werb, Zena and Lu, Pengfei},
article_location = {Washington},
article_number = {39},
doi = {http://dx.doi.org/10.1073/pnas.1611532113},
keywords = {branching morphogenesis; FGF signaling; EGF signaling; epithelial-stromal interactions; stromal microenvironment},
language = {eng},
issn = {0027-8424},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
title = {SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling},
volume = {113},
year = {2016}
}
TY - JOUR
ID - 1363696
AU - Koledová, Zuzana - Zhang, Xiaohong - Streuli, Charles - Clarke, Robert B. - Klein, Ophir D. - Werb, Zena - Lu, Pengfei
PY - 2016
TI - SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling
JF - Proceedings of the National Academy of Sciences of the United States of America
VL - 113
IS - 39
SP - "E5731"-"E5740"
EP - "E5731"-"E5740"
PB - National Academy of Sciences
SN - 00278424
KW - branching morphogenesis
KW - FGF signaling
KW - EGF signaling
KW - epithelial-stromal interactions
KW - stromal microenvironment
N2 - The role of the local microenvironment in influencing cell behavior is central to both normal development and cancer formation. Here, we show that sprouty 1 (SPRY1) modulates the microenvironment to enable proper mammary branching morphogenesis. This process occurs through negative regulation of epidermal growth factor receptor (EGFR) signaling in mammary stroma. Loss of SPRY1 resulted in up-regulation of EGFR-extracellular signal-regulated kinase (ERK) signaling in response to amphiregulin and transforming growth factor alpha stimulation. Consequently, stromal paracrine signaling and ECM remodeling is augmented, leading to increased epithelial branching in themutant gland. By contrast, down-regulation of EGFR-ERK signaling due to gain of Sprouty function in the stroma led to stunted epithelial branching. Taken together, our results show that modulation of stromal paracrine signaling and ECM remodeling by SPRY1 regulates mammary epithelial morphogenesis during postnatal development.
ER -
KOLEDOVÁ, Zuzana, Xiaohong ZHANG, Charles STREULI, Robert B. CLARKE, Ophir D. KLEIN, Zena WERB and Pengfei LU. SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling. \textit{Proceedings of the National Academy of Sciences of the United States of America}. Washington: National Academy of Sciences, 2016, vol.~113, No~39, p.~''E5731''-''E5740'', 10 pp. ISSN~0027-8424. Available from: https://dx.doi.org/10.1073/pnas.1611532113.
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