EISENBERGER, Martin, Alan BULAVA, Josef KAUTZNER, Petr NEUZIL, Ales MOKRACEK, Jiri HANIS and Ladislav DUŠEK. Sequential Hybrid CryoMaze Ablation versus Surgical CryoMaze Alone for the Treatment of Atrial Fibrillation (SurHyb): study protocol for a randomized controlled trial. Trials. London: BioMed Central, 2016, vol. 17, No 518, p. 1-7. ISSN 1745-6215. Available from: https://dx.doi.org/10.1186/s13063-016-1634-4.
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Basic information
Original name Sequential Hybrid CryoMaze Ablation versus Surgical CryoMaze Alone for the Treatment of Atrial Fibrillation (SurHyb): study protocol for a randomized controlled trial
Authors EISENBERGER, Martin (203 Czech Republic), Alan BULAVA (203 Czech Republic), Josef KAUTZNER (203 Czech Republic), Petr NEUZIL (203 Czech Republic), Ales MOKRACEK (203 Czech Republic), Jiri HANIS (203 Czech Republic) and Ladislav DUŠEK (203 Czech Republic, guarantor, belonging to the institution).
Edition Trials, London, BioMed Central, 2016, 1745-6215.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30201 Cardiac and Cardiovascular systems
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.969
RIV identification code RIV/00216224:14110/16:00092164
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1186/s13063-016-1634-4
UT WoS 000386077600003
Keywords in English Atrial fibrillation; Catheter ablation; Surgical ablation; CryoMaze; Randomized controlled clinical trial; Hybrid approach
Tags EL OK
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 6/12/2016 12:27.
Abstract
Background: Atrial fibrillation is common in patients with structural heart disease who are undergoing cardiac surgery. Surgical CryoMaze has been shown to be an effective treatment in several trials, but success rates have varied considerably, between 47-95 %. The sequential hybrid approach, combining surgical CryoMaze followed by radiofrequency catheter ablation, can achieve high freedom from atrial arrhythmias, even when rigorous methods to detect arrhythmias after the procedure are used. However, data from randomized trials comparing hybrid ablations to surgical ablations alone are lacking. Methods/Design: The SurHyb study is a prospective, multicenter, randomized study. Patients with persistent or long-standing persistent atrial fibrillation will be randomized to either surgical CryoMaze alone or surgical CryoMaze followed by catheter ablation 3 months post-surgery. The primary outcome measure is arrhythmia-free survival without class I or III antiarrhythmic drugs, which will be evaluated using 7-day ECG Holter monitoring at 24 months. A total of 260 patients will be investigated from three medical centers in the Czech Republic to obtain the relevant information. Discussion: This is the first randomized study that compares surgical CryoMaze alone with the staged hybrid surgical CryoMaze followed by catheter ablation in patients with persistent or long-standing persistent atrial fibrillation. These results will contribute to the optimization of the treatment for these patients.
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