Detailed Information on Publication Record
2016
Isolation of Treponema DNA from Necrophagous Flies in a Natural Ecosystem
KNAUF, Sascha, Jane RAPHAEL, Oriol MITJÀ, Inyasi A. V. LEJORA, Idrissa S. CHUMA et. al.Basic information
Original name
Isolation of Treponema DNA from Necrophagous Flies in a Natural Ecosystem
Authors
KNAUF, Sascha (276 Germany), Jane RAPHAEL (834 Tanzania, United Republic of), Oriol MITJÀ (724 Spain), Inyasi A. V. LEJORA (834 Tanzania, United Republic of), Idrissa S. CHUMA (834 Tanzania, United Republic of), Emmanuel K. BATAMUZI (834 Tanzania, United Republic of), Julius D. KEYYU (834 Tanzania, United Republic of), Robert FYUMAGWA (834 Tanzania, United Republic of), Simone LÜERT (276 Germany), Charmie GODORNES (840 United States of America), Hsi LIU (840 United States of America), Christiane SCHWARZ (276 Germany), David ŠMAJS (203 Czech Republic, guarantor, belonging to the institution), Philippe GRANGE (250 France), Dietmar ZINNER (276 Germany), Christian ROOS (276 Germany) and Sheila A. LUKEHART (840 United States of America)
Edition
EBioMedicine, Amsterdam, Elsevier Science BV, 2016, 2352-3964
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30300 3.3 Health sciences
Country of publisher
Netherlands
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14110/16:00092217
Organization unit
Faculty of Medicine
UT WoS
000386878100021
Keywords in English
Treponema pallidum; Dipteria; Yaws; Nonhuman primates; Transmission
Tags
Tags
International impact, Reviewed
Změněno: 8/12/2016 15:31, Ing. Mgr. Věra Pospíšilíková
Abstract
V originále
Background: Recently, the World Health Organization launched a campaign to eradicate the tropical disease yaws, caused by the bacterium Treponema pallidum subsp. pertenue; however, for decades researchers have questioned whether flies act as a vector for the pathogen that could facilitate transmission. Methods: A total of 207 fly specimens were trapped in areas of Africa in which T. pallidum-induced skin ulcerations are common in wild baboons; 88 flies from Tarangire National Park and 119 from Lake Manyara National Park in Tanzania were analyzed by PCR for the presence of T. pallidum DNA. Findings: We report that in the two study areas, T. pallidum DNA was found in 17-24% of wild-caught flies of the order Diptera. Treponemal DNA sequences obtained from many of the flies match sequences derived from nearby baboon T. pallidum strains, and one of the fly species with an especially high prevalence of T. pallidum DNA, Musca sorbens, has previously been shown to transmit yaws in an experimental setting. Interpretation: Our results raise the possibility that flies play a role in yaws transmission; further research is warranted, given how important understanding transmission is for the eradication of this disfiguring disease.