CTRP1: A Molecular Link between Obesity and Hypertension

J 2016

CTRP1: A Molecular Link between Obesity and Hypertension

CHALUPOVÁ, Lenka, H. HALUPOVÁ, Alena ŽÁKOVSKÁ, G. KREJČÍ, M. ŠVESTÁK et. al.

Basic information

Original name

CTRP1: A Molecular Link between Obesity and Hypertension

Authors

CHALUPOVÁ, Lenka (203 Czech Republic, belonging to the institution), H. HALUPOVÁ (203 Czech Republic), Alena ŽÁKOVSKÁ (203 Czech Republic, belonging to the institution), G. KREJČÍ (203 Czech Republic, guarantor), M. ŠVESTÁK (203 Czech Republic) and D. STEJSKAL (203 Czech Republic)

Edition

J Mol Biomark Diagn, 2016, 2155-9929

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30102 Immunology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14310/16:00092224

Organization unit

Faculty of Science

Keywords in English

CTRP1; Aldosterone; ELISA; Obesity; Hypertension; Metabolic syndrome; Diabetic nephropathy

Abstract

V originále

Abstract Background: CTRP1, a recently identified adipokine, was found to stimulate aldosterone production. Serum CTRP1 and plasma Aldosterone levels were significantly increased in patients with diabetes mellitus and metabolic syndrome. Therefore, it would be interesting to investigate whether the secretion of CTRP1 in human serum is associated with hypertension as well as with diabetes mellitus. Aim: This study evaluated serum CTRP1 and aldosterone concentrations in healthy individuals and in patients with diabetic nephropathy. Methods: Serum samples from 32 healthy individuals and 44 patients with diabetic nephropathy were measured for CTRP1, Aldosterone, diabetes-related biomarkers and renal disease-related biomarkers by enzyme-linked immunosorbent assay (ELISA). Results: Correlation analyses showed that serum CTRP1 in healthy individuals was not correlated with any other biochemical parameters or laboratory characteristic; however, in patients with diabetic nephropathy, a significant correlation was found between serum CTRP1 and Aldosterone (P=0.003), Urea, Cystatin C and ANGPTL4. Aldosterone level was significantly higher in subjects with diabetic nephropathy compared to healthy subjects (P=0.01). Discussion: Our results demonstrated that the adipokine CTRP1 is significantly associated with Aldosterone and support the hypothesis that CTRP1 may be a newly identified molecular link between obesity and hypertension.

Citovat

CHALUPOVÁ, Lenka, H. HALUPOVÁ, Alena ŽÁKOVSKÁ, G. KREJČÍ, M. ŠVESTÁK and D. STEJSKAL. CTRP1: A Molecular Link between Obesity and Hypertension (CTRP1: A Molecular Link between Obesity and HypertensionCha). J Mol Biomark Diagn. 2016, vol. 7, No 4, p. 1-5. ISSN 2155-9929.

@article{1364147,
   author = {Chalupová, Lenka and Halupová, H. and Žákovská, Alena and Krejčí, G. and Švesták, M. and Stejskal, D.},
   article_number = {4},
   keywords = {CTRP1; Aldosterone; ELISA; Obesity; Hypertension; Metabolic syndrome; Diabetic nephropathy},
   language = {eng},
   issn = {2155-9929},
   journal = {J Mol Biomark Diagn},
   title = {CTRP1: A Molecular Link between Obesity and Hypertension},
   volume = {7},
   year = {2016}
}

TY  - JOUR
ID  - 1364147
AU  - Chalupová, Lenka - Halupová, H. - Žákovská, Alena - Krejčí, G. - Švesták, M. - Stejskal, D.
PY  - 2016
TI  - CTRP1: A Molecular Link between Obesity and Hypertension
JF  - J Mol Biomark Diagn
VL  - 7
IS  - 4
SP  - 1-5
EP  - 1-5
SN  - 21559929
KW  - CTRP1
KW  - Aldosterone
KW  - ELISA
KW  - Obesity
KW  - Hypertension
KW  - Metabolic syndrome
KW  - Diabetic nephropathy
N2  - Abstract Background: CTRP1, a recently identified adipokine, was found to stimulate aldosterone production. Serum CTRP1 and plasma Aldosterone levels were significantly increased in patients with diabetes mellitus and metabolic syndrome. Therefore, it would be interesting to investigate whether the secretion of CTRP1 in human serum is associated with hypertension as well as with diabetes mellitus. Aim: This study evaluated serum CTRP1 and aldosterone concentrations in healthy individuals and in patients with diabetic nephropathy. Methods: Serum samples from 32 healthy individuals and 44 patients with diabetic nephropathy were measured for CTRP1, Aldosterone, diabetes-related biomarkers and renal disease-related biomarkers by enzyme-linked immunosorbent assay (ELISA). Results: Correlation analyses showed that serum CTRP1 in healthy individuals was not correlated with any other biochemical parameters or laboratory characteristic; however, in patients with diabetic nephropathy, a significant correlation was found between serum CTRP1 and Aldosterone (P=0.003), Urea, Cystatin C and ANGPTL4. Aldosterone level was significantly higher in subjects with diabetic nephropathy compared to healthy subjects (P=0.01). Discussion: Our results demonstrated that the adipokine CTRP1 is significantly associated with Aldosterone and support the hypothesis that CTRP1 may be a newly identified molecular link between obesity and hypertension.
ER  -

CHALUPOVÁ, Lenka, H. HALUPOVÁ, Alena ŽÁKOVSKÁ, G. KREJČÍ, M. ŠVESTÁK and D. STEJSKAL. CTRP1: A Molecular Link between Obesity and Hypertension (CTRP1: A Molecular Link between Obesity and HypertensionCha). \textit{J Mol Biomark Diagn}. 2016, vol.~7, No~4, p.~1-5. ISSN~2155-9929.

Detailed Information on Publication Record