DRAŽANOVÁ, Eva, Jana RUDÁ, Lucie GROSSOVÁ, Kateřina HORSKÁ, Hana KOTOLOVÁ, Zuzana BABINSKÁ and Zenon STARČUK. The influence of chronic application of olazapine on brain perfusion in rat. In ESMRMB 2016. 2016. ISSN 0968-5243.
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Basic information
Original name The influence of chronic application of olazapine on brain perfusion in rat
Authors DRAŽANOVÁ, Eva (203 Czech Republic, guarantor), Jana RUDÁ (203 Czech Republic, belonging to the institution), Lucie GROSSOVÁ (203 Czech Republic), Kateřina HORSKÁ (203 Czech Republic), Hana KOTOLOVÁ (203 Czech Republic), Zuzana BABINSKÁ (703 Slovakia, belonging to the institution) and Zenon STARČUK (203 Czech Republic).
Edition ESMRMB 2016, 2016.
Other information
Original language English
Type of outcome Conference abstract
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Germany
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 1.718
RIV identification code RIV/00216224:14110/16:00092302
Organization unit Faculty of Medicine
ISSN 0968-5243
Keywords in English MRI perfusion olanzapine rat ASL
Tags EL OK
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 13/7/2020 10:01.
Abstract
Olanzapin is a commonly used atypical antipsychotic drug. We hypothesize that long term therapy of olanzapin could alter region dependent blood brain perfusion, which we tested by arterial spin labeling (ASL) MR imaging. Statistical evaluation of the ASL results in the hippocampus, somatosensory cortex and piriform cortex revealed significantly lower somatosensory cortex perfusion in olanzapin-treated animals.
Links
MUNI/A/1116/2014, interní kód MUName: Nové farmakologické mechanizmy v preklinickém i klinickém vývoji léčiv
Investor: Masaryk University, Category A
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