| DUMKOVÁ, Jana, Lucie VRLIKOVA, Zbynek VECERA, Barbora PUTNOVA, Bohumil DOCEKAL, Pavel MIKUSKA, Petr FICTUM, Aleš HAMPL and marcela BUCHTOVÁ. Inhaled Cadmium Oxide Nanoparticles: Their in Vivo Fate and Effect on Target Organs. International Journal of Molecular Sciences. Basel: Multidisciplinary Digital Publishing Institute (MDPI), 2016, vol. 17, No 6, p. nestránkováno, 20 pp. ISSN 1422-0067. Available from: https://dx.doi.org/10.3390/ijms17060874. |
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@article{1364892,
author = {Dumková, Jana and Vrlikova, Lucie and Vecera, Zbynek and Putnova, Barbora and Docekal, Bohumil and Mikuska, Pavel and Fictum, Petr and Hampl, Aleš and Buchtová, marcela},
article_location = {Basel},
article_number = {6},
doi = {http://dx.doi.org/10.3390/ijms17060874},
keywords = {nanoparticles; cadmium oxide; electron microscopy; toxicity; inhalation; lung; liver; kidney; spleen},
language = {eng},
issn = {1422-0067},
journal = {International Journal of Molecular Sciences},
title = {Inhaled Cadmium Oxide Nanoparticles: Their in Vivo Fate and Effect on Target Organs},
volume = {17},
year = {2016}
}
TY - JOUR
ID - 1364892
AU - Dumková, Jana - Vrlikova, Lucie - Vecera, Zbynek - Putnova, Barbora - Docekal, Bohumil - Mikuska, Pavel - Fictum, Petr - Hampl, Aleš - Buchtová, marcela
PY - 2016
TI - Inhaled Cadmium Oxide Nanoparticles: Their in Vivo Fate and Effect on Target Organs
JF - International Journal of Molecular Sciences
VL - 17
IS - 6
SP - nestránkováno
EP - nestránkováno
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SN - 14220067
KW - nanoparticles
KW - cadmium oxide
KW - electron microscopy
KW - toxicity
KW - inhalation
KW - lung
KW - liver
KW - kidney
KW - spleen
N2 - The increasing amount of heavy metals used in manufacturing equivalently increases hazards of environmental pollution by industrial products such as cadmium oxide (CdO) nanoparticles. Here, we aimed to unravel the CdO nanoparticle destiny upon their entry into lungs by inhalations, with the main focus on the ultrastructural changes that the nanoparticles may cause to tissues of the primary and secondary target organs. We indeed found the CdO nanoparticles to be transported from the lungs into secondary target organs by blood. In lungs, inhaled CdO nanoparticles caused significant alterations in parenchyma tissue including hyperemia, enlarged pulmonary septa, congested capillaries, alveolar emphysema and small areas of atelectasis. Nanoparticles were observed in the cytoplasm of cells lining bronchioles, in the alveolar spaces as well as inside the membranous pneumocytes and in phagosomes of lung macrophages. Nanoparticles even penetrated through the membrane into some organelles including mitochondria and they also accumulated in the cytoplasmic vesicles. In livers, inhalation caused periportal inflammation and local hepatic necrosis. Only minor changes such as diffusely thickened filtration membrane with intramembranous electron dense deposits were observed in kidney. Taken together, inhaled CdO nanoparticles not only accumulated in lungs but they were also transported to other organs causing serious damage at tissue as well as cellular level.
ER -
DUMKOVÁ, Jana, Lucie VRLIKOVA, Zbynek VECERA, Barbora PUTNOVA, Bohumil DOCEKAL, Pavel MIKUSKA, Petr FICTUM, Aleš HAMPL and marcela BUCHTOVÁ. Inhaled Cadmium Oxide Nanoparticles: Their in Vivo Fate and Effect on Target Organs. \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute (MDPI), 2016, vol.~17, No~6, p.~nestránkováno, 20 pp. ISSN~1422-0067. Available from: https://dx.doi.org/10.3390/ijms17060874.
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