UHRIKOVA, I., P. SCHEER, J. HLOZKOVA, P. SUCHY and Milan SEPŠI. Effects of acetylsalicylic acid on coagulation tests and haptoglobin concentrations in rabbits with permanent transvenous pacing. Veterinarni Medicina. Prague: Czech Academy of Agricultural Sciences, 2016, vol. 61, No 9, p. 528-532. ISSN 0375-8427. Available from: https://dx.doi.org/10.17221/33/2016-VETMED.
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Basic information
Original name Effects of acetylsalicylic acid on coagulation tests and haptoglobin concentrations in rabbits with permanent transvenous pacing
Authors UHRIKOVA, I. (203 Czech Republic), P. SCHEER (203 Czech Republic), J. HLOZKOVA (203 Czech Republic), P. SUCHY (203 Czech Republic) and Milan SEPŠI (203 Czech Republic, guarantor, belonging to the institution).
Edition Veterinarni Medicina, Prague, Czech Academy of Agricultural Sciences, 2016, 0375-8427.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30201 Cardiac and Cardiovascular systems
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 0.489
RIV identification code RIV/00216224:14110/16:00092318
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.17221/33/2016-VETMED
UT WoS 000383994500006
Keywords in English inflammation; D-dimers; pacemaker; Oryctolagus
Tags EL OK
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 13/12/2016 20:28.
Abstract
The aim of this study was to evaluate changes in coagulation tests, haptoglobin concentrations and leukocyte counts in rabbits with right-ventricle pacing medicated with acetylsalicylic acid (ASA). Blood was collected from 35 non-anaesthetised males from the jugular vein at baseline, one and two months after pacemaker implantation. Animals were divided into two groups: non-medicated and medicated with ASA. Total leukocyte and platelet counts were measured on an automatic veterinary flow cytometry haematological analyser. Prothrombin time, activated partial thromboplastin time, fibrinogen levels and D-dimers were determined from citrated blood. We found significantly elevated activated partial thromboplastin times and prothrombin times in ASA in comparison to the control group, but not within the ASA group over time. We also observed a decrease in platelet counts in the control group over time, but not in comparison to the ASA group. No significant changes in total leukocyte counts and haptoglobin concentrations were detected. Medication with ASA may alter coagulation profiles in rabbits with permanent transvenous pacing.
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