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@proceedings{1364957,
author = {Jířík, Radovan and Taxt, Torfin and Souček, Karel and Kratochvíla, Jiří and Macíček, Ondřej and Dražanová, Eva and Starčuk, Zenon},
keywords = {pharmakokinetic model cancer mouse perfusion},
language = {eng},
title = {Comparison of the ATH and 2CXM models using low- and high-molecular-weight contrast agents in DCE-MRI},
url = {http://link.springer.com/journal/10334/29/1/suppl/page/1},
year = {2016}
}
TY - CONF
ID - 1364957
AU - Jířík, Radovan - Taxt, Torfin - Souček, Karel - Kratochvíla, Jiří - Macíček, Ondřej - Dražanová, Eva - Starčuk, Zenon
PY - 2016
TI - Comparison of the ATH and 2CXM models using low- and high-molecular-weight contrast agents in DCE-MRI
KW - pharmakokinetic model cancer mouse perfusion
UR - http://link.springer.com/journal/10334/29/1/suppl/page/1
N2 - In DCE-MRI, tissue contrast-agent (CA) concentration curves are modeled as a convolution of the arterial input function (AIF) and the impulse residue function (IRF). The 2CXM and ATH models [1] are the most widely used advanced IRF models that provide separate estimates of blood flow, Fb, and permeability- surface area product, PS, contrary to the commonly applied Tofts models. No consensus exists on which advanced pharmacokinetic model is better. Simulation-based and blind-deconvolution-based preclinical model comparisons are published. This contribution presents a new model-evaluation method based on high- and low-molecular weight (MW) contrast-agents administered within one examination. Some perfusion parameters are expected to be MW-independent (namely Fb and blood volume—vb), while PS should decrease with increasing MW.
ER -
JÍŘÍK, Radovan, Torfin TAXT, Karel SOUČEK, Jiří KRATOCHVÍLA, Ondřej MACÍČEK, Eva DRAŽANOVÁ a Zenon STARČUK. \textit{Comparison of the ATH and 2CXM models using low- and high-molecular-weight contrast agents in DCE-MRI}. Online. 2016, [citováno 2024-04-23]
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