| REKTOROVÁ, Irena, Jiri MEKYSKA, Eva KORIŤÁKOVÁ, Milena KOŠŤÁLOVÁ, Ilona ELIÁŠOVÁ, Martina MRAČKOVÁ, Dagmar BERÁNKOVÁ, Tereza NEČASOVÁ, Zdenek SMEKAL and Radek MAREČEK. Speech prosody impairment predicts cognitive decline in Parkinson's disease. Online. PARKINSONISM & RELATED DISORDERS. OXFORD: ELSEVIER SCI LTD, 2016, vol. 29, August, p. 90-95. ISSN 1353-8020. Available from: https://dx.doi.org/10.1016/j.parkreldis.2016.05.018. [citováno 2024-04-23] |
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@article{1364980,
author = {Rektorová, Irena and Mekyska, Jiri and Koriťáková, Eva and Košťálová, Milena and Eliášová, Ilona and Mračková, Martina and Beránková, Dagmar and Nečasová, Tereza and Smekal, Zdenek and Mareček, Radek},
article_location = {OXFORD},
article_number = {August},
doi = {http://dx.doi.org/10.1016/j.parkreldis.2016.05.018},
keywords = {Parkinson's disease; Speech prosody; Acoustic analysis; Cognitive; Dementia},
language = {eng},
issn = {1353-8020},
journal = {PARKINSONISM & RELATED DISORDERS},
title = {Speech prosody impairment predicts cognitive decline in Parkinson's disease},
url = {http://ac.els-cdn.com/S1353802016301705/1-s2.0-S1353802016301705-main.pdf?_tid=788e4f5c-c2a7-11e6-b780-00000aacb362&acdnat=1481793702_a0f60c8ee72ca0836953a9099a5fb278},
volume = {29},
year = {2016}
}
TY - JOUR
ID - 1364980
AU - Rektorová, Irena - Mekyska, Jiri - Koriťáková, Eva - Košťálová, Milena - Eliášová, Ilona - Mračková, Martina - Beránková, Dagmar - Nečasová, Tereza - Smekal, Zdenek - Mareček, Radek
PY - 2016
TI - Speech prosody impairment predicts cognitive decline in Parkinson's disease
JF - PARKINSONISM & RELATED DISORDERS
VL - 29
IS - August
SP - 90-95
EP - 90-95
PB - ELSEVIER SCI LTD
SN - 13538020
KW - Parkinson's disease
KW - Speech prosody
KW - Acoustic analysis
KW - Cognitive
KW - Dementia
UR - http://ac.els-cdn.com/S1353802016301705/1-s2.0-S1353802016301705-main.pdf?_tid=788e4f5c-c2a7-11e6-b780-00000aacb362&acdnat=1481793702_a0f60c8ee72ca0836953a9099a5fb278
L2 - http://ac.els-cdn.com/S1353802016301705/1-s2.0-S1353802016301705-main.pdf?_tid=788e4f5c-c2a7-11e6-b780-00000aacb362&acdnat=1481793702_a0f60c8ee72ca0836953a9099a5fb278
N2 - Background: Impairment of speech prosody is characteristic for Parkinson's disease (PD) and does not respond well to dopaminergic treatment. Objectives: We assessed whether baseline acoustic parameters, alone or in combination with other predominantly non-dopaminergic symptoms may predict global cognitive decline as measured by the Addenbrooke's cognitive examination (ACE-R) and/or worsening of cognitive status as assessed by a detailed neuropsychological examination. Methods: Forty-four consecutive non-depressed PD patients underwent clinical and cognitive testing, and acoustic voice analysis at baseline and at the two-year follow-up. Influence of speech and other clinical parameters on worsening of the ACE-R and of the cognitive status was analyzed using linear and logistic regression. Results: The cognitive status (classified as normal cognition, mild cognitive impairment and dementia) deteriorated in 25% of patients during the follow-up. The multivariate linear regression model consisted of the variation in range of the fundamental voice frequency (F0VR) and the REM Sleep Behavioral Disorder Screening Questionnaire (RBDSQ). These parameters explained 37.2% of the variability of the change in ACE-R. The most significant predictors in the univariate logistic regression were the speech index of rhythmicity (SPIR; p = 0.012), disease duration (p = 0.019), and the RBDSQ (p = 0.032). The multivariate regression analysis revealed that SPIR alone led to 73.2% accuracy in predicting a change in cognitive status. Combining SPIR with RBDSQ improved the prediction accuracy of SPIR alone by 73%. Conclusions: Impairment of speech prosody together with symptoms of RBD predicted rapid cognitive decline and worsening of PD cognitive status during a two-year period. (C) 2016 Elsevier Ltd. All rights reserved.
ER -
REKTOROVÁ, Irena, Jiri MEKYSKA, Eva KORIŤÁKOVÁ, Milena KOŠŤÁLOVÁ, Ilona ELIÁŠOVÁ, Martina MRAČKOVÁ, Dagmar BERÁNKOVÁ, Tereza NEČASOVÁ, Zdenek SMEKAL and Radek MAREČEK. Speech prosody impairment predicts cognitive decline in Parkinson's disease. Online. \textit{PARKINSONISM \&{} RELATED DISORDERS}. OXFORD: ELSEVIER SCI LTD, 2016, vol.~29, August, p.~90-95. ISSN~1353-8020. Available from: https://dx.doi.org/10.1016/j.parkreldis.2016.05.018. [citováno 2024-04-23]
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