Speech prosody impairment predicts cognitive decline in
Parkinson's disease

J 2016

Speech prosody impairment predicts cognitive decline in Parkinson's disease

REKTOROVÁ, Irena, Jiri MEKYSKA, Eva KORIŤÁKOVÁ, Milena KOŠŤÁLOVÁ, Ilona ELIÁŠOVÁ et. al.

Basic information

Original name

Speech prosody impairment predicts cognitive decline in Parkinson's disease

Authors

REKTOROVÁ, Irena (203 Czech Republic, guarantor, belonging to the institution), Jiri MEKYSKA (203 Czech Republic), Eva KORIŤÁKOVÁ (203 Czech Republic, belonging to the institution), Milena KOŠŤÁLOVÁ (203 Czech Republic, belonging to the institution), Ilona ELIÁŠOVÁ (203 Czech Republic, belonging to the institution), Martina MRAČKOVÁ (203 Czech Republic, belonging to the institution), Dagmar BERÁNKOVÁ (203 Czech Republic, belonging to the institution), Tereza NEČASOVÁ (203 Czech Republic, belonging to the institution), Zdenek SMEKAL (203 Czech Republic) and Radek MAREČEK (203 Czech Republic, belonging to the institution)

Edition

PARKINSONISM & RELATED DISORDERS, OXFORD, ELSEVIER SCI LTD, 2016, 1353-8020

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.484

RIV identification code

RIV/00216224:14740/16:00088928

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1016/j.parkreldis.2016.05.018

UT WoS

000381955700016

Keywords in English

Parkinson's disease; Speech prosody; Acoustic analysis; Cognitive; Dementia

Abstract

V originále

Background: Impairment of speech prosody is characteristic for Parkinson's disease (PD) and does not respond well to dopaminergic treatment. Objectives: We assessed whether baseline acoustic parameters, alone or in combination with other predominantly non-dopaminergic symptoms may predict global cognitive decline as measured by the Addenbrooke's cognitive examination (ACE-R) and/or worsening of cognitive status as assessed by a detailed neuropsychological examination. Methods: Forty-four consecutive non-depressed PD patients underwent clinical and cognitive testing, and acoustic voice analysis at baseline and at the two-year follow-up. Influence of speech and other clinical parameters on worsening of the ACE-R and of the cognitive status was analyzed using linear and logistic regression. Results: The cognitive status (classified as normal cognition, mild cognitive impairment and dementia) deteriorated in 25% of patients during the follow-up. The multivariate linear regression model consisted of the variation in range of the fundamental voice frequency (F0VR) and the REM Sleep Behavioral Disorder Screening Questionnaire (RBDSQ). These parameters explained 37.2% of the variability of the change in ACE-R. The most significant predictors in the univariate logistic regression were the speech index of rhythmicity (SPIR; p = 0.012), disease duration (p = 0.019), and the RBDSQ (p = 0.032). The multivariate regression analysis revealed that SPIR alone led to 73.2% accuracy in predicting a change in cognitive status. Combining SPIR with RBDSQ improved the prediction accuracy of SPIR alone by 73%. Conclusions: Impairment of speech prosody together with symptoms of RBD predicted rapid cognitive decline and worsening of PD cognitive status during a two-year period. (C) 2016 Elsevier Ltd. All rights reserved.

Links

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

NT13499, research and development project

Name: Řeč, její poruchy a kognitivní funkce u Parkinsonovy nemoci

NV16-30805A, research and development project

Name: Efekt neinvazivní stimulace mozku na hypokinetickou dysartrii, mikrografii a mozkovou plasticitu u pacientů s Parkinsonovou nemocí

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Citovat

REKTOROVÁ, Irena, Jiri MEKYSKA, Eva KORIŤÁKOVÁ, Milena KOŠŤÁLOVÁ, Ilona ELIÁŠOVÁ, Martina MRAČKOVÁ, Dagmar BERÁNKOVÁ, Tereza NEČASOVÁ, Zdenek SMEKAL and Radek MAREČEK. Speech prosody impairment predicts cognitive decline in Parkinson's disease. PARKINSONISM & RELATED DISORDERS. OXFORD: ELSEVIER SCI LTD, 2016, vol. 29, August, p. 90-95. ISSN 1353-8020. Available from: https://dx.doi.org/10.1016/j.parkreldis.2016.05.018.

@article{1364980,
   author = {Rektorová, Irena and Mekyska, Jiri and Koriťáková, Eva and Košťálová, Milena and Eliášová, Ilona and Mračková, Martina and Beránková, Dagmar and Nečasová, Tereza and Smekal, Zdenek and Mareček, Radek},
   article_location = {OXFORD},
   article_number = {August},
   doi = {http://dx.doi.org/10.1016/j.parkreldis.2016.05.018},
   keywords = {Parkinson's disease; Speech prosody; Acoustic analysis; Cognitive; Dementia},
   language = {eng},
   issn = {1353-8020},
   journal = {PARKINSONISM & RELATED DISORDERS},
   title = {Speech prosody impairment predicts cognitive decline in Parkinson's disease},
   url = {http://ac.els-cdn.com/S1353802016301705/1-s2.0-S1353802016301705-main.pdf?_tid=788e4f5c-c2a7-11e6-b780-00000aacb362&acdnat=1481793702_a0f60c8ee72ca0836953a9099a5fb278},
   volume = {29},
   year = {2016}
}

TY  - JOUR
ID  - 1364980
AU  - Rektorová, Irena - Mekyska, Jiri - Koriťáková, Eva - Košťálová, Milena - Eliášová, Ilona - Mračková, Martina - Beránková, Dagmar - Nečasová, Tereza - Smekal, Zdenek - Mareček, Radek
PY  - 2016
TI  - Speech prosody impairment predicts cognitive decline in Parkinson's disease
JF  - PARKINSONISM & RELATED DISORDERS
VL  - 29
IS  - August
SP  - 90-95
EP  - 90-95
PB  - ELSEVIER SCI LTD
SN  - 13538020
KW  - Parkinson's disease
KW  - Speech prosody
KW  - Acoustic analysis
KW  - Cognitive
KW  - Dementia
UR  - http://ac.els-cdn.com/S1353802016301705/1-s2.0-S1353802016301705-main.pdf?_tid=788e4f5c-c2a7-11e6-b780-00000aacb362&acdnat=1481793702_a0f60c8ee72ca0836953a9099a5fb278
L2  - http://ac.els-cdn.com/S1353802016301705/1-s2.0-S1353802016301705-main.pdf?_tid=788e4f5c-c2a7-11e6-b780-00000aacb362&acdnat=1481793702_a0f60c8ee72ca0836953a9099a5fb278
N2  - Background: Impairment of speech prosody is characteristic for Parkinson's disease (PD) and does not respond well to dopaminergic treatment. Objectives: We assessed whether baseline acoustic parameters, alone or in combination with other predominantly non-dopaminergic symptoms may predict global cognitive decline as measured by the Addenbrooke's cognitive examination (ACE-R) and/or worsening of cognitive status as assessed by a detailed neuropsychological examination. Methods: Forty-four consecutive non-depressed PD patients underwent clinical and cognitive testing, and acoustic voice analysis at baseline and at the two-year follow-up. Influence of speech and other clinical parameters on worsening of the ACE-R and of the cognitive status was analyzed using linear and logistic regression. Results: The cognitive status (classified as normal cognition, mild cognitive impairment and dementia) deteriorated in 25% of patients during the follow-up. The multivariate linear regression model consisted of the variation in range of the fundamental voice frequency (F0VR) and the REM Sleep Behavioral Disorder Screening Questionnaire (RBDSQ). These parameters explained 37.2% of the variability of the change in ACE-R. The most significant predictors in the univariate logistic regression were the speech index of rhythmicity (SPIR; p = 0.012), disease duration (p = 0.019), and the RBDSQ (p = 0.032). The multivariate regression analysis revealed that SPIR alone led to 73.2% accuracy in predicting a change in cognitive status. Combining SPIR with RBDSQ improved the prediction accuracy of SPIR alone by 73%. Conclusions: Impairment of speech prosody together with symptoms of RBD predicted rapid cognitive decline and worsening of PD cognitive status during a two-year period. (C) 2016 Elsevier Ltd. All rights reserved.
ER  -

REKTOROVÁ, Irena, Jiri MEKYSKA, Eva KORIŤÁKOVÁ, Milena KOŠŤÁLOVÁ, Ilona ELIÁŠOVÁ, Martina MRAČKOVÁ, Dagmar BERÁNKOVÁ, Tereza NEČASOVÁ, Zdenek SMEKAL and Radek MAREČEK. Speech prosody impairment predicts cognitive decline in Parkinson's disease. \textit{PARKINSONISM \&{} RELATED DISORDERS}. OXFORD: ELSEVIER SCI LTD, 2016, vol.~29, August, p.~90-95. ISSN~1353-8020. Available from: https://dx.doi.org/10.1016/j.parkreldis.2016.05.018.

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