| LINKE, F., M. HARENBERG, M.M. NIETERT, S. ZAUNIG, von Bonin F., A. ARLT, M. SZCZEPANOWSKI, HA WEICH, S. LUTZ, C. DULLIN, Pavlína JANOVSKÁ, Michaela KRAFČÍKOVÁ, Lukáš TRANTÍREK, Petra OVESNÁ, W. KLAPPER, T. BEISSBARTH, F. ALVES, Vítězslav BRYJA, L. TRÜMPER, J. WILTING and Dieter KUBE. Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma. Leukemia. London: Nature Publishing Group, 2017, vol. 31, No 2, p. 361-372. ISSN 0887-6924. Available from: https://dx.doi.org/10.1038/leu.2016.232. |
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@article{1365014,
author = {Linke, F. and Harenberg, M. and Nietert, M.M. and Zaunig, S. and F., von Bonin and Arlt, A. and Szczepanowski, M. and Weich, HA and Lutz, S. and Dullin, C. and Janovská, Pavlína and Krafčíková, Michaela and Trantírek, Lukáš and Ovesná, Petra and Klapper, W. and Beissbarth, T. and Alves, F. and Bryja, Vítězslav and Trümper, L. and Wilting, J. and Kube, Dieter},
article_location = {London},
article_number = {2},
doi = {http://dx.doi.org/10.1038/leu.2016.232},
keywords = {CHRONIC LYMPHOCYTIC-LEUKEMIA; CHEMOKINE RECEPTOR CCR7; FUNCTIONAL CD30 LIGAND; GROWTH-FACTOR; CONSTITUTIVE ACTIVATION; TUMOR; EXPRESSION; DISEASE; DISSEMINATION; VEGF},
language = {eng},
issn = {0887-6924},
journal = {Leukemia},
title = {Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma},
url = {https://www.nature.com/articles/leu2016232},
volume = {31},
year = {2017}
}
TY - JOUR
ID - 1365014
AU - Linke, F. - Harenberg, M. - Nietert, M.M. - Zaunig, S. - F., von Bonin - Arlt, A. - Szczepanowski, M. - Weich, HA - Lutz, S. - Dullin, C. - Janovská, Pavlína - Krafčíková, Michaela - Trantírek, Lukáš - Ovesná, Petra - Klapper, W. - Beissbarth, T. - Alves, F. - Bryja, Vítězslav - Trümper, L. - Wilting, J. - Kube, Dieter
PY - 2017
TI - Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma
JF - Leukemia
VL - 31
IS - 2
SP - 361-372
EP - 361-372
PB - Nature Publishing Group
SN - 08876924
KW - CHRONIC LYMPHOCYTIC-LEUKEMIA
KW - CHEMOKINE RECEPTOR CCR7
KW - FUNCTIONAL CD30 LIGAND
KW - GROWTH-FACTOR
KW - CONSTITUTIVE ACTIVATION
KW - TUMOR
KW - EXPRESSION
KW - DISEASE
KW - DISSEMINATION
KW - VEGF
UR - https://www.nature.com/articles/leu2016232
L2 - https://www.nature.com/articles/leu2016232
N2 - The interaction between vascular endothelial cells (ECs) and cancer cells is of vital importance to understand tumor dissemination. A paradigmatic cancer to study cell-cell interactions is classical Hodgkin Lymphoma (cHL) owing to its complex microenvironment. The role of the interplay between cHL and ECs remains poorly understood. Here we identify canonical WNT pathway activity as important for the mutual interactions between cHL cells and ECs. We demonstrate that local canonical WNT signaling activates cHL cell chemotaxis toward ECs, adhesion to EC layers and cell invasion using not only the Wnt-inhibitor Dickkopf, tankyrases and casein kinase 1 inhibitors but also knockdown of the lymphocyte enhancer binding-factor 1 (LEF-1) and beta-catenin in cHL cells. Furthermore, LEF-1- and beta-catenin-regulated cHL secretome promoted EC migration, sprouting and vascular tube formation involving vascular endothelial growth factor A (VEGF-A). Importantly, high VEGFA expression is associated with a worse overall survival of cHL patients. These findings strongly support the concept that WNTs might function as a regulator of lymphoma dissemination by affecting cHL cell chemotaxis and promoting EC behavior and thus angiogenesis through paracrine interactions.
ER -
LINKE, F., M. HARENBERG, M.M. NIETERT, S. ZAUNIG, von Bonin F., A. ARLT, M. SZCZEPANOWSKI, HA WEICH, S. LUTZ, C. DULLIN, Pavlína JANOVSKÁ, Michaela KRAFČÍKOVÁ, Lukáš TRANTÍREK, Petra OVESNÁ, W. KLAPPER, T. BEISSBARTH, F. ALVES, Vítězslav BRYJA, L. TRÜMPER, J. WILTING and Dieter KUBE. Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma. \textit{Leukemia}. London: Nature Publishing Group, 2017, vol.~31, No~2, p.~361-372. ISSN~0887-6924. Available from: https://dx.doi.org/10.1038/leu.2016.232.
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