Microenvironmental interactions between endothelial and
lymphoma cells: a role for the canonical WNT pathway in Hodgkin
lymphoma

J 2017

Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma

LINKE, F., M. HARENBERG, M.M. NIETERT, S. ZAUNIG, von Bonin F. et. al.

Basic information

Original name

Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma

Authors

LINKE, F. (276 Germany), M. HARENBERG (276 Germany), M.M. NIETERT (276 Germany), S. ZAUNIG (276 Germany), von Bonin F. (276 Germany), A. ARLT (276 Germany), M. SZCZEPANOWSKI (276 Germany), HA WEICH (276 Germany), S. LUTZ (276 Germany), C. DULLIN (276 Germany), Pavlína JANOVSKÁ (203 Czech Republic, belonging to the institution), Michaela KRAFČÍKOVÁ (203 Czech Republic, belonging to the institution), Lukáš TRANTÍREK (203 Czech Republic, belonging to the institution), Petra OVESNÁ (203 Czech Republic, belonging to the institution), W. KLAPPER (276 Germany), T. BEISSBARTH (276 Germany), F. ALVES (276 Germany), Vítězslav BRYJA (203 Czech Republic, belonging to the institution), L. TRÜMPER (276 Germany), J. WILTING (276 Germany) and Dieter KUBE (276 Germany, guarantor)

Edition

Leukemia, London, Nature Publishing Group, 2017, 0887-6924

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 10.023

RIV identification code

RIV/00216224:14310/17:00095626

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1038/leu.2016.232

UT WoS

000394058800012

Keywords in English

CHRONIC LYMPHOCYTIC-LEUKEMIA; CHEMOKINE RECEPTOR CCR7; FUNCTIONAL CD30 LIGAND; GROWTH-FACTOR; CONSTITUTIVE ACTIVATION; TUMOR; EXPRESSION; DISEASE; DISSEMINATION; VEGF

Abstract

V originále

The interaction between vascular endothelial cells (ECs) and cancer cells is of vital importance to understand tumor dissemination. A paradigmatic cancer to study cell-cell interactions is classical Hodgkin Lymphoma (cHL) owing to its complex microenvironment. The role of the interplay between cHL and ECs remains poorly understood. Here we identify canonical WNT pathway activity as important for the mutual interactions between cHL cells and ECs. We demonstrate that local canonical WNT signaling activates cHL cell chemotaxis toward ECs, adhesion to EC layers and cell invasion using not only the Wnt-inhibitor Dickkopf, tankyrases and casein kinase 1 inhibitors but also knockdown of the lymphocyte enhancer binding-factor 1 (LEF-1) and beta-catenin in cHL cells. Furthermore, LEF-1- and beta-catenin-regulated cHL secretome promoted EC migration, sprouting and vascular tube formation involving vascular endothelial growth factor A (VEGF-A). Importantly, high VEGFA expression is associated with a worse overall survival of cHL patients. These findings strongly support the concept that WNTs might function as a regulator of lymphoma dissemination by affecting cHL cell chemotaxis and promoting EC behavior and thus angiogenesis through paracrine interactions.

Links

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

NV15-29793A, research and development project

Name: Analýza Wnt/PCP jako nástroj pro lepší management chronické lymfocytární leukémie

Citovat

LINKE, F., M. HARENBERG, M.M. NIETERT, S. ZAUNIG, von Bonin F., A. ARLT, M. SZCZEPANOWSKI, HA WEICH, S. LUTZ, C. DULLIN, Pavlína JANOVSKÁ, Michaela KRAFČÍKOVÁ, Lukáš TRANTÍREK, Petra OVESNÁ, W. KLAPPER, T. BEISSBARTH, F. ALVES, Vítězslav BRYJA, L. TRÜMPER, J. WILTING and Dieter KUBE. Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma. Leukemia. London: Nature Publishing Group, 2017, vol. 31, No 2, p. 361-372. ISSN 0887-6924. Available from: https://dx.doi.org/10.1038/leu.2016.232.

@article{1365014,
   author = {Linke, F. and Harenberg, M. and Nietert, M.M. and Zaunig, S. and F., von Bonin and Arlt, A. and Szczepanowski, M. and Weich, HA and Lutz, S. and Dullin, C. and Janovská, Pavlína and Krafčíková, Michaela and Trantírek, Lukáš and Ovesná, Petra and Klapper, W. and Beissbarth, T. and Alves, F. and Bryja, Vítězslav and Trümper, L. and Wilting, J. and Kube, Dieter},
   article_location = {London},
   article_number = {2},
   doi = {http://dx.doi.org/10.1038/leu.2016.232},
   keywords = {CHRONIC LYMPHOCYTIC-LEUKEMIA; CHEMOKINE RECEPTOR CCR7; FUNCTIONAL CD30 LIGAND; GROWTH-FACTOR; CONSTITUTIVE ACTIVATION; TUMOR; EXPRESSION; DISEASE; DISSEMINATION; VEGF},
   language = {eng},
   issn = {0887-6924},
   journal = {Leukemia},
   title = {Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma},
   url = {https://www.nature.com/articles/leu2016232},
   volume = {31},
   year = {2017}
}

TY  - JOUR
ID  - 1365014
AU  - Linke, F. - Harenberg, M. - Nietert, M.M. - Zaunig, S. - F., von Bonin - Arlt, A. - Szczepanowski, M. - Weich, HA - Lutz, S. - Dullin, C. - Janovská, Pavlína - Krafčíková, Michaela - Trantírek, Lukáš - Ovesná, Petra - Klapper, W. - Beissbarth, T. - Alves, F. - Bryja, Vítězslav - Trümper, L. - Wilting, J. - Kube, Dieter
PY  - 2017
TI  - Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma
JF  - Leukemia
VL  - 31
IS  - 2
SP  - 361-372
EP  - 361-372
PB  - Nature Publishing Group
SN  - 08876924
KW  - CHRONIC LYMPHOCYTIC-LEUKEMIA
KW  - CHEMOKINE RECEPTOR CCR7
KW  - FUNCTIONAL CD30 LIGAND
KW  - GROWTH-FACTOR
KW  - CONSTITUTIVE ACTIVATION
KW  - TUMOR
KW  - EXPRESSION
KW  - DISEASE
KW  - DISSEMINATION
KW  - VEGF
UR  - https://www.nature.com/articles/leu2016232
L2  - https://www.nature.com/articles/leu2016232
N2  - The interaction between vascular endothelial cells (ECs) and cancer cells is of vital importance to understand tumor dissemination. A paradigmatic cancer to study cell-cell interactions is classical Hodgkin Lymphoma (cHL) owing to its complex microenvironment. The role of the interplay between cHL and ECs remains poorly understood. Here we identify canonical WNT pathway activity as important for the mutual interactions between cHL cells and ECs. We demonstrate that local canonical WNT signaling activates cHL cell chemotaxis toward ECs, adhesion to EC layers and cell invasion using not only the Wnt-inhibitor Dickkopf, tankyrases and casein kinase 1 inhibitors but also knockdown of the lymphocyte enhancer binding-factor 1 (LEF-1) and beta-catenin in cHL cells. Furthermore, LEF-1- and beta-catenin-regulated cHL secretome promoted EC migration, sprouting and vascular tube formation involving vascular endothelial growth factor A (VEGF-A). Importantly, high VEGFA expression is associated with a worse overall survival of cHL patients. These findings strongly support the concept that WNTs might function as a regulator of lymphoma dissemination by affecting cHL cell chemotaxis and promoting EC behavior and thus angiogenesis through paracrine interactions.
ER  -

LINKE, F., M. HARENBERG, M.M. NIETERT, S. ZAUNIG, von Bonin F., A. ARLT, M. SZCZEPANOWSKI, HA WEICH, S. LUTZ, C. DULLIN, Pavlína JANOVSKÁ, Michaela KRAFČÍKOVÁ, Lukáš TRANTÍREK, Petra OVESNÁ, W. KLAPPER, T. BEISSBARTH, F. ALVES, Vítězslav BRYJA, L. TRÜMPER, J. WILTING and Dieter KUBE. Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma. \textit{Leukemia}. London: Nature Publishing Group, 2017, vol.~31, No~2, p.~361-372. ISSN~0887-6924. Available from: https://dx.doi.org/10.1038/leu.2016.232.

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