| LOŠÁK, Jan, Jitka HÜTTLOVÁ, Petra LIPOVÁ, Radek MAREČEK, Martin BAREŠ, Pavel FILIP, Jozef ŽÚBOR, Libor USTOHAL, Jiří VANÍČEK a Tomáš KAŠPÁREK. Predictive Motor Timing and the Cerebellar Vermis in Schizophrenia: An fMRI Study. Schizophrenia Bulletin. Oxford: Oxford University Press, 2016, roč. 42, č. 6, s. 1517-1527. ISSN 0586-7614. Dostupné z: https://dx.doi.org/10.1093/schbul/sbw065. |
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@article{1365208,
author = {Lošák, Jan and Hüttlová, Jitka and Lipová, Petra and Mareček, Radek and Bareš, Martin and Filip, Pavel and Žúbor, Jozef and Ustohal, Libor and Vaníček, Jiří and Kašpárek, Tomáš},
article_location = {Oxford},
article_number = {6},
doi = {http://dx.doi.org/10.1093/schbul/sbw065},
keywords = {predictive timing; cognitive dysmetria; schizophrenia; cerebellum; fMRI; dopamine},
language = {eng},
issn = {0586-7614},
journal = {Schizophrenia Bulletin},
title = {Predictive Motor Timing and the Cerebellar Vermis in Schizophrenia: An fMRI Study},
volume = {42},
year = {2016}
}
TY - JOUR
ID - 1365208
AU - Lošák, Jan - Hüttlová, Jitka - Lipová, Petra - Mareček, Radek - Bareš, Martin - Filip, Pavel - Žúbor, Jozef - Ustohal, Libor - Vaníček, Jiří - Kašpárek, Tomáš
PY - 2016
TI - Predictive Motor Timing and the Cerebellar Vermis in Schizophrenia: An fMRI Study
JF - Schizophrenia Bulletin
VL - 42
IS - 6
SP - 1517-1527
EP - 1517-1527
PB - Oxford University Press
SN - 05867614
KW - predictive timing
KW - cognitive dysmetria
KW - schizophrenia
KW - cerebellum
KW - fMRI
KW - dopamine
N2 - Abnormalities in both time processing and dopamine (DA) neurotransmission have been observed in schizophrenia. Time processing seems to be linked to DA neurotransmission. The cognitive dysmetria hypothesis postulates that psychosis might be a manifestation of the loss of coordination of mental processes due to impaired timing. The objective of the present study was to analyze timing abilities and their corresponding functional neuroanatomy in schizophrenia. We performed a functional magnetic resonance imaging (fMRI) study using a predictive motor timing paradigm in 28 schizophrenia patients and 27 matched healthy controls (HC). The schizophrenia patients showed accelerated time processing compared to HC; the amount of the acceleration positively correlated with the degree of positive psychotic symptoms and negatively correlated with antipsychotic dose. This dysfunctional predictive timing was associated with BOLD signal activity alterations in several brain networks, especially those previously described as timing networks (basal ganglia, cerebellum, SMA, and insula) and reward networks (hippocampus, amygdala, and NAcc). BOLD signal activity in the cerebellar vermis was negatively associated with accelerated time processing. Several lines of evidence suggest a direct link between DA transmission and the cerebellar vermis that could explain their relevance for the neurobiology of schizophrenia.
ER -
LOŠÁK, Jan, Jitka HÜTTLOVÁ, Petra LIPOVÁ, Radek MAREČEK, Martin BAREŠ, Pavel FILIP, Jozef ŽÚBOR, Libor USTOHAL, Jiří VANÍČEK a Tomáš KAŠPÁREK. Predictive Motor Timing and the Cerebellar Vermis in Schizophrenia: An fMRI Study. \textit{Schizophrenia Bulletin}. Oxford: Oxford University Press, 2016, roč.~42, č.~6, s.~1517-1527. ISSN~0586-7614. Dostupné z: https://dx.doi.org/10.1093/schbul/sbw065.
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