Predictive Motor Timing and the Cerebellar Vermis in
Schizophrenia: An fMRI Study

J 2016

Predictive Motor Timing and the Cerebellar Vermis in Schizophrenia: An fMRI Study

LOŠÁK, Jan, Jitka HÜTTLOVÁ, Petra LIPOVÁ, Radek MAREČEK, Martin BAREŠ et. al.

Basic information

Original name

Predictive Motor Timing and the Cerebellar Vermis in Schizophrenia: An fMRI Study

Authors

LOŠÁK, Jan (203 Czech Republic, guarantor, belonging to the institution), Jitka HÜTTLOVÁ (203 Czech Republic, belonging to the institution), Petra LIPOVÁ (203 Czech Republic, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Martin BAREŠ (203 Czech Republic, belonging to the institution), Pavel FILIP (703 Slovakia, belonging to the institution), Jozef ŽÚBOR (703 Slovakia, belonging to the institution), Libor USTOHAL (203 Czech Republic, belonging to the institution), Jiří VANÍČEK (203 Czech Republic, belonging to the institution) and Tomáš KAŠPÁREK (203 Czech Republic, belonging to the institution)

Edition

Schizophrenia Bulletin, Oxford, Oxford University Press, 2016, 0586-7614

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 7.575

RIV identification code

RIV/00216224:14110/16:00088932

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1093/schbul/sbw065

UT WoS

000388029100026

Keywords in English

predictive timing; cognitive dysmetria; schizophrenia; cerebellum; fMRI; dopamine

Abstract

V originále

Abnormalities in both time processing and dopamine (DA) neurotransmission have been observed in schizophrenia. Time processing seems to be linked to DA neurotransmission. The cognitive dysmetria hypothesis postulates that psychosis might be a manifestation of the loss of coordination of mental processes due to impaired timing. The objective of the present study was to analyze timing abilities and their corresponding functional neuroanatomy in schizophrenia. We performed a functional magnetic resonance imaging (fMRI) study using a predictive motor timing paradigm in 28 schizophrenia patients and 27 matched healthy controls (HC). The schizophrenia patients showed accelerated time processing compared to HC; the amount of the acceleration positively correlated with the degree of positive psychotic symptoms and negatively correlated with antipsychotic dose. This dysfunctional predictive timing was associated with BOLD signal activity alterations in several brain networks, especially those previously described as timing networks (basal ganglia, cerebellum, SMA, and insula) and reward networks (hippocampus, amygdala, and NAcc). BOLD signal activity in the cerebellar vermis was negatively associated with accelerated time processing. Several lines of evidence suggest a direct link between DA transmission and the cerebellar vermis that could explain their relevance for the neurobiology of schizophrenia.

Links

NV15-31063A, research and development project

Name: Buněčné markery vedoucí ke specifické léčbě "na míru" schizofrenním pacientům

Files attached

EL_1365208.pdf

Request the author's version of the file

Citovat

LOŠÁK, Jan, Jitka HÜTTLOVÁ, Petra LIPOVÁ, Radek MAREČEK, Martin BAREŠ, Pavel FILIP, Jozef ŽÚBOR, Libor USTOHAL, Jiří VANÍČEK and Tomáš KAŠPÁREK. Predictive Motor Timing and the Cerebellar Vermis in Schizophrenia: An fMRI Study. Schizophrenia Bulletin. Oxford: Oxford University Press, 2016, vol. 42, No 6, p. 1517-1527. ISSN 0586-7614. Available from: https://dx.doi.org/10.1093/schbul/sbw065.

@article{1365208,
   author = {Lošák, Jan and Hüttlová, Jitka and Lipová, Petra and Mareček, Radek and Bareš, Martin and Filip, Pavel and Žúbor, Jozef and Ustohal, Libor and Vaníček, Jiří and Kašpárek, Tomáš},
   article_location = {Oxford},
   article_number = {6},
   doi = {http://dx.doi.org/10.1093/schbul/sbw065},
   keywords = {predictive timing; cognitive dysmetria; schizophrenia; cerebellum; fMRI; dopamine},
   language = {eng},
   issn = {0586-7614},
   journal = {Schizophrenia Bulletin},
   title = {Predictive Motor Timing and the Cerebellar Vermis in Schizophrenia: An fMRI Study},
   volume = {42},
   year = {2016}
}

TY  - JOUR
ID  - 1365208
AU  - Lošák, Jan - Hüttlová, Jitka - Lipová, Petra - Mareček, Radek - Bareš, Martin - Filip, Pavel - Žúbor, Jozef - Ustohal, Libor - Vaníček, Jiří - Kašpárek, Tomáš
PY  - 2016
TI  - Predictive Motor Timing and the Cerebellar Vermis in Schizophrenia: An fMRI Study
JF  - Schizophrenia Bulletin
VL  - 42
IS  - 6
SP  - 1517-1527
EP  - 1517-1527
PB  - Oxford University Press
SN  - 05867614
KW  - predictive timing
KW  - cognitive dysmetria
KW  - schizophrenia
KW  - cerebellum
KW  - fMRI
KW  - dopamine
N2  - Abnormalities in both time processing and dopamine (DA) neurotransmission have been observed in schizophrenia. Time processing seems to be linked to DA neurotransmission. The cognitive dysmetria hypothesis postulates that psychosis might be a manifestation of the loss of coordination of mental processes due to impaired timing. The objective of the present study was to analyze timing abilities and their corresponding functional neuroanatomy in schizophrenia. We performed a functional magnetic resonance imaging (fMRI) study using a predictive motor timing paradigm in 28 schizophrenia patients and 27 matched healthy controls (HC). The schizophrenia patients showed accelerated time processing compared to HC; the amount of the acceleration positively correlated with the degree of positive psychotic symptoms and negatively correlated with antipsychotic dose. This dysfunctional predictive timing was associated with BOLD signal activity alterations in several brain networks, especially those previously described as timing networks (basal ganglia, cerebellum, SMA, and insula) and reward networks (hippocampus, amygdala, and NAcc). BOLD signal activity in the cerebellar vermis was negatively associated with accelerated time processing. Several lines of evidence suggest a direct link between DA transmission and the cerebellar vermis that could explain their relevance for the neurobiology of schizophrenia.
ER  -

LOŠÁK, Jan, Jitka HÜTTLOVÁ, Petra LIPOVÁ, Radek MAREČEK, Martin BAREŠ, Pavel FILIP, Jozef ŽÚBOR, Libor USTOHAL, Jiří VANÍČEK and Tomáš KAŠPÁREK. Predictive Motor Timing and the Cerebellar Vermis in Schizophrenia: An fMRI Study. \textit{Schizophrenia Bulletin}. Oxford: Oxford University Press, 2016, vol.~42, No~6, p.~1517-1527. ISSN~0586-7614. Available from: https://dx.doi.org/10.1093/schbul/sbw065.

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