Origin of modern syphilis and emergence of a pandemic Treponema
pallidum cluster

J 2017

Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster

ARORA, Natasha, Verena J. SCHUENEMANN, Günter JÄGER, Alexander PELTZER, Alexander SEITZ et. al.

Basic information

Original name

Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster

Authors

ARORA, Natasha (756 Switzerland), Verena J. SCHUENEMANN (276 Germany), Günter JÄGER (276 Germany), Alexander PELTZER (276 Germany), Alexander SEITZ (276 Germany), Alexander HERBIG (276 Germany), Michal STROUHAL (203 Czech Republic, belonging to the institution), Linda GRILLOVÁ (203 Czech Republic, belonging to the institution), Leonor SÁNCHEZ-BUSÓ (724 Spain), Denise KÜHNERT (756 Switzerland), Kirsten I. BOS (276 Germany), Leyla Rivero DAVIS (756 Switzerland), Lenka MIKALOVÁ (203 Czech Republic, belonging to the institution), Sylvia BRUISTEN (528 Netherlands), Peter KOMERICKI (40 Austria), Patrik FRENCH (826 United Kingdom of Great Britain and Northern Ireland), Paul R. GRANT (826 United Kingdom of Great Britain and Northern Ireland), María A. PANDO (32 Argentina), Lucía Gallo VAULET (32 Argentina), Marcelo Rodríguez FERMEPIN (32 Argentina), Antonio MARTINEZ (724 Spain), Arturo Centurion LARA (840 United States of America), Lorenzo GIACANI (840 United States of America), Steven J. NORRIS (840 United States of America), David ŠMAJS (203 Czech Republic, guarantor, belonging to the institution), Philipp BOSSHARD (756 Switzerland), Fernando GONZÁLEZ-CANDELAS (724 Spain), Kay NIESELT (276 Germany), Johannes KRAUSE (276 Germany) and Homayoun C. BAGHERI (756 Switzerland)

Edition

Nature Microbiology, London, Nature Publishing Group, 2017, 2058-5276

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10606 Microbiology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 14.174

RIV identification code

RIV/00216224:14110/17:00095975

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1038/nmicrobiol.2016.245

UT WoS

000396366300023

Keywords in English

syphilis; Treponema pallidum

Abstract

V originále

The abrupt onslaught of the syphilis pandemic that started in the late fifteenth century established this devastating infectious disease as one of the most feared in human history 1. Surprisingly, despite the availability of effective antibiotic treatment since the mid-twentieth century, this bacterial infection, which is caused by Treponema pallidum subsp. pallidum (TPA), has been re-emerging globally in the last few decades with an estimated 10.6 million cases in 2008 (ref. 2). Although resistance to penicillin has not yet been identified, an increasing number of strains fail to respond to the second-line antibiotic azithromycin 3. Little is known about the genetic patterns in current infections or the evolutionary origins of the disease due to the low quantities of treponemal DNA in clinical samples and difficulties in cultivating the pathogen 4. Here, we used DNA capture and whole-genome sequencing to successfully interrogate genome-wide variation from syphilis patient specimens, combined with laboratory samples of TPA and two other subspecies. Phylogenetic comparisons based on the sequenced genomes indicate that the TPA strains examined share a common ancestor after the fifteenth century, within the early modern era. Moreover, most contemporary strains are azithromycin-resistant and are members of a globally dominant cluster, named here as SS14-omega. The cluster diversified from a common ancestor in the mid-twentieth century subsequent to the discovery of antibiotics. Its recent phylogenetic divergence and global presence point to the emergence of a pandemic strain cluster.

Links

ROZV/20/LF/2015, interní kód MU

Name: LF - Příspěvek IP 2015

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

ARORA, Natasha, Verena J. SCHUENEMANN, Günter JÄGER, Alexander PELTZER, Alexander SEITZ, Alexander HERBIG, Michal STROUHAL, Linda GRILLOVÁ, Leonor SÁNCHEZ-BUSÓ, Denise KÜHNERT, Kirsten I. BOS, Leyla Rivero DAVIS, Lenka MIKALOVÁ, Sylvia BRUISTEN, Peter KOMERICKI, Patrik FRENCH, Paul R. GRANT, María A. PANDO, Lucía Gallo VAULET, Marcelo Rodríguez FERMEPIN, Antonio MARTINEZ, Arturo Centurion LARA, Lorenzo GIACANI, Steven J. NORRIS, David ŠMAJS, Philipp BOSSHARD, Fernando GONZÁLEZ-CANDELAS, Kay NIESELT, Johannes KRAUSE and Homayoun C. BAGHERI. Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster. Nature Microbiology. London: Nature Publishing Group, 2017, vol. 2, No 1, p. 1-6. ISSN 2058-5276. Available from: https://dx.doi.org/10.1038/nmicrobiol.2016.245.

@article{1365624,
   author = {Arora, Natasha and Schuenemann, Verena J. and Jäger, Günter and Peltzer, Alexander and Seitz, Alexander and Herbig, Alexander and Strouhal, Michal and Grillová, Linda and SánchezandBusó, Leonor and Kühnert, Denise and Bos, Kirsten I. and Davis, Leyla Rivero and Mikalová, Lenka and Bruisten, Sylvia and Komericki, Peter and French, Patrik and Grant, Paul R. and Pando, María A. and Vaulet, Lucía Gallo and Fermepin, Marcelo Rodríguez and Martinez, Antonio and Lara, Arturo Centurion and Giacani, Lorenzo and Norris, Steven J. and Šmajs, David and Bosshard, Philipp and GonzálezandCandelas, Fernando and Nieselt, Kay and Krause, Johannes and Bagheri, Homayoun C.},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/nmicrobiol.2016.245},
   keywords = {syphilis; Treponema pallidum},
   language = {eng},
   issn = {2058-5276},
   journal = {Nature Microbiology},
   title = {Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster},
   volume = {2},
   year = {2017}
}

TY  - JOUR
ID  - 1365624
AU  - Arora, Natasha - Schuenemann, Verena J. - Jäger, Günter - Peltzer, Alexander - Seitz, Alexander - Herbig, Alexander - Strouhal, Michal - Grillová, Linda - Sánchez-Busó, Leonor - Kühnert, Denise - Bos, Kirsten I. - Davis, Leyla Rivero - Mikalová, Lenka - Bruisten, Sylvia - Komericki, Peter - French, Patrik - Grant, Paul R. - Pando, María A. - Vaulet, Lucía Gallo - Fermepin, Marcelo Rodríguez - Martinez, Antonio - Lara, Arturo Centurion - Giacani, Lorenzo - Norris, Steven J. - Šmajs, David - Bosshard, Philipp - González-Candelas, Fernando - Nieselt, Kay - Krause, Johannes - Bagheri, Homayoun C.
PY  - 2017
TI  - Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster
JF  - Nature Microbiology
VL  - 2
IS  - 1
SP  - 1-6
EP  - 1-6
PB  - Nature Publishing Group
SN  - 20585276
KW  - syphilis
KW  - Treponema pallidum
N2  - The abrupt onslaught of the syphilis pandemic that started in the late fifteenth century established this devastating infectious disease as one of the most feared in human history 1. Surprisingly, despite the availability of effective antibiotic treatment since the mid-twentieth century, this bacterial infection, which is caused by Treponema pallidum subsp. pallidum (TPA), has been re-emerging globally in the last few decades with an estimated 10.6 million cases in 2008 (ref. 2). Although resistance to penicillin has not yet been identified, an increasing number of strains fail to respond to the second-line antibiotic azithromycin 3. Little is known about the genetic patterns in current infections or the evolutionary origins of the disease due to the low quantities of treponemal DNA in clinical samples and difficulties in cultivating the pathogen 4. Here, we used DNA capture and whole-genome sequencing to successfully interrogate genome-wide variation from syphilis patient specimens, combined with laboratory samples of TPA and two other subspecies. Phylogenetic comparisons based on the sequenced genomes indicate that the TPA strains examined share a common ancestor after the fifteenth century, within the early modern era. Moreover, most contemporary strains are azithromycin-resistant and are members of a globally dominant cluster, named here as SS14-omega. The cluster diversified from a common ancestor in the mid-twentieth century subsequent to the discovery of antibiotics. Its recent phylogenetic divergence and global presence point to the emergence of a pandemic strain cluster.
ER  -

ARORA, Natasha, Verena J. SCHUENEMANN, Günter JÄGER, Alexander PELTZER, Alexander SEITZ, Alexander HERBIG, Michal STROUHAL, Linda GRILLOVÁ, Leonor SÁNCHEZ-BUSÓ, Denise KÜHNERT, Kirsten I. BOS, Leyla Rivero DAVIS, Lenka MIKALOVÁ, Sylvia BRUISTEN, Peter KOMERICKI, Patrik FRENCH, Paul R. GRANT, María A. PANDO, Lucía Gallo VAULET, Marcelo Rodríguez FERMEPIN, Antonio MARTINEZ, Arturo Centurion LARA, Lorenzo GIACANI, Steven J. NORRIS, David ŠMAJS, Philipp BOSSHARD, Fernando GONZÁLEZ-CANDELAS, Kay NIESELT, Johannes KRAUSE and Homayoun C. BAGHERI. Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster. \textit{Nature Microbiology}. London: Nature Publishing Group, 2017, vol.~2, No~1, p.~1-6. ISSN~2058-5276. Available from: https://dx.doi.org/10.1038/nmicrobiol.2016.245.

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