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@article{1365764,
author = {Zerhau, Pavel and Mackerle, Zdeněk and Husár, Matej and Sochůrková, Daniela and Brichtová, Eva and Gopfert, Eduard and Faldyna, Martin and Kubát, Martin and Plánka, Ladislav},
article_location = {Basel},
article_number = {4},
doi = {http://dx.doi.org/10.1159/000448851},
keywords = {Detrusor response; Micturition reflex arc; Nerve rerouting; Neurostimulation; Ventral spinal roots},
language = {eng},
issn = {0042-1138},
journal = {Urologia Internationalis},
title = {Experimental Electrophysiological and Pressure Responses of Urinary Bladder Detrusor to Lumbar to Sacral Nerve Rerouting - An Animal Study with Negative Results},
volume = {97},
year = {2016}
}
TY - JOUR
ID - 1365764
AU - Zerhau, Pavel - Mackerle, Zdeněk - Husár, Matej - Sochůrková, Daniela - Brichtová, Eva - Gopfert, Eduard - Faldyna, Martin - Kubát, Martin - Plánka, Ladislav
PY - 2016
TI - Experimental Electrophysiological and Pressure Responses of Urinary Bladder Detrusor to Lumbar to Sacral Nerve Rerouting - An Animal Study with Negative Results
JF - Urologia Internationalis
VL - 97
IS - 4
SP - 421-428
EP - 421-428
PB - Karger
SN - 00421138
KW - Detrusor response
KW - Micturition reflex arc
KW - Nerve rerouting
KW - Neurostimulation
KW - Ventral spinal roots
N2 - Background/Aims/Objectives: To verify the transfer of evoked potentials through anastomosis of an experimentally created micturition reflex arc and to detect said potentials directly on the detrusor and sphincter of rabbit urinary bladder. Methods: During 2013-2015, 17 rabbits were operated upon and measurement followed during reoperation 3-16 months later. Suitable ventral spinal roots were electrophysiologically detected following laminectomy, and a somatic-central nervous system-Autonomic micturition reflex arc was created. During reoperation, the ventral root was stimulated above and below the anastomosis, the evoked potentials on the bladder detrusor and sphincter were measured, and intravesical pressure was monitored. Results: With stimulation above the anastomosis, 9 animals (53%) displayed a urinary bladder detrusor response and 7 (41%) a sphincter response. Four rabbits (24%) had elevated intravesical pressure. During the control stimulation below the anastomosis, we detected a detrusor response in 7 animals (41%), a sphincter response in 5 (29%), and elevated pressure in 4 (24%). Neither induction of micturition nor decrease in external sphincter activity occurred. Conclusions: Creation of a somatic-CNS-Autonomic reflex arc is technically possible. However reflex activity transferring through the anastomosis is detectable on the detrusor only in some individuals, and is unable to induce a micturition reflex with or without accompanying detrusor-sphincter dyssynergia.
ER -
ZERHAU, Pavel, Zdeněk MACKERLE, Matej HUSÁR, Daniela SOCHŮRKOVÁ, Eva BRICHTOVÁ, Eduard GOPFERT, Martin FALDYNA, Martin KUBÁT and Ladislav PLÁNKA. Experimental Electrophysiological and Pressure Responses of Urinary Bladder Detrusor to Lumbar to Sacral Nerve Rerouting - An Animal Study with Negative Results. \textit{Urologia Internationalis}. Basel: Karger, 2016, vol.~97, No~4, p.~421-428. ISSN~0042-1138. Available from: https://dx.doi.org/10.1159/000448851.
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