Non-anaplastic peripheral T cell lymphoma in children and adolescents-an international review of 143 cases

MELLGREN, K., A. ATTARBASCHI, O. ABLA, S. ALEXANDER, S. BOMKEN, E. BUBANSKA, A. CHIANG, M. CSÓKA, A. FEDOROVA, E. KABICKOVA, L. KAPUSCINSKA-KEMBLOWSKA, R. KOBAYASHI, Zdenka KŘENOVÁ, F. MEYER-WENTRUP, N. MIAKOVA, M. PILLON, G. PLAT, A. UYTTEBROECK, D. WILLIAMS, G. WRÓBEL and U. KONTNY. Non-anaplastic peripheral T cell lymphoma in children and adolescents-an international review of 143 cases. Annals of hematology. New York: Springer Verlag, 2016, vol. 95, No 8, p. 1295-1305. ISSN 0939-5555. Available from: https://dx.doi.org/10.1007/s00277-016-2722-y.

Basic information

• Original name: Non-anaplastic peripheral T cell lymphoma in children and adolescents-an international review of 143 cases
• Authors: MELLGREN, K. (752 Sweden), A. ATTARBASCHI (40 Austria), O. ABLA (124 Canada), S. ALEXANDER (124 Canada), S. BOMKEN (826 United Kingdom of Great Britain and Northern Ireland), E. BUBANSKA (703 Slovakia), A. CHIANG (156 China), M. CSÓKA (348 Hungary), A. FEDOROVA (112 Belarus), E. KABICKOVA (203 Czech Republic), L. KAPUSCINSKA-KEMBLOWSKA (616 Poland), R. KOBAYASHI (392 Japan), Zdenka KŘENOVÁ (203 Czech Republic, guarantor, belonging to the institution), F. MEYER-WENTRUP (528 Netherlands), N. MIAKOVA (643 Russian Federation), M. PILLON (380 Italy), G. PLAT (250 France), A. UYTTEBROECK (56 Belgium), D. WILLIAMS (826 United Kingdom of Great Britain and Northern Ireland), G. WRÓBEL (616 Poland) and U. KONTNY (276 Germany).
• Edition: Annals of hematology, New York, Springer Verlag, 2016, 0939-5555.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30200 3.2 Clinical medicine
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 3.083
• RIV identification code: RIV/00216224:14110/16:00092588
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1007/s00277-016-2722-y
• UT WoS: 000379189100010
• Keywords in English: Peripheral Tcell lymphoma; Non-Hodgkin's lymphoma; Subtypes; Prognosis
• Tags: EL OK
• Tags: International impact, Reviewed

Abstract

Peripheral T cell lymphomas (PTCL) are rare in children and adolescents, and data about outcome and treatment results are scarce. The present study is a joint, international, retrospective analysis of 143 reported cases of non-anaplastic PTCL in patients < 19 years of age, with a focus on treatment and outcome features. One hundred forty-three patients, between 0.3 and 18.7 years old, diagnosed between 2000 and 2015 were included in the study. PTCL not otherwise specified was the largest subgroup, followed by extranodal NK/T cell lymphoma, hepatosplenic T cell lymphoma (HS TCL), and subcutaneous panniculitis-like T cell lymphoma (SP TCL). Probability of overall survival (pOS) at 5 years for the whole group was 0.56 +/- 0.05, and probability of event-free survival was (pEFS) 0.45 +/- 0.05. Patients with SP TCL had a good outcome with 5-year pOS of 0.78 +/- 0.1 while patients with HS TCL were reported with 5-year pOS of only 0.13 +/- 0.12. Twenty-five percent of the patients were reported to have a pre-existing condition, and this group had a dismal outcome with 5-year pOS of 0.29 +/- 0.09. The distribution of non-anaplastic PTCL subtypes in pediatric and adolescent patients differs from what is reported in adult patients. Overall outcome depends on the subtype with some doing better than others. Pre-existing conditions are frequent and associated with poor outcomes. There is a clear need for subtype-based treatment recommendations for children and adolescents with PTCL.