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@article{1366834,
author = {Svobodová, Blanka and Barros, Lillian and Calhelha, Ricardo C. and Heleno, Sandrina and Alves, Maria Jose and Walcott, Simone and Bittová, Miroslava and Kubáň, Vlastimil and Ferreira, Isabel C.F.R.},
article_location = {AMSTERDAM},
article_number = {January},
doi = {http://dx.doi.org/10.1016/j.indcrop.2016.10.046},
keywords = {Antioxidant; Anti-inflammatory; Antimicrobial activity; Cytotoxicity; Phenolic compounds; Momordica charantia L.},
language = {eng},
issn = {0926-6690},
journal = {Industrial Crops and Products},
title = {Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago},
url = {http://www.sciencedirect.com/science/article/pii/S0926669016307336},
volume = {95},
year = {2017}
}
TY - JOUR
ID - 1366834
AU - Svobodová, Blanka - Barros, Lillian - Calhelha, Ricardo C. - Heleno, Sandrina - Alves, Maria Jose - Walcott, Simone - Bittová, Miroslava - Kubáň, Vlastimil - Ferreira, Isabel C.F.R.
PY - 2017
TI - Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago
JF - Industrial Crops and Products
VL - 95
IS - January
SP - 365-373
EP - 365-373
PB - ELSEVIER SCIENCE BV
SN - 09266690
KW - Antioxidant
KW - Anti-inflammatory
KW - Antimicrobial activity
KW - Cytotoxicity
KW - Phenolic compounds
KW - Momordica charantia L.
UR - http://www.sciencedirect.com/science/article/pii/S0926669016307336
L2 - http://www.sciencedirect.com/science/article/pii/S0926669016307336
N2 - A wild variety of bitter melon Momordica charantia L. (Cucurbitaceae) has been used in bush medicine of Trinidad and Tobago for treatment of diabetes, inflammations and cancer. Despite many studies regarding the cultivated bitter melon, the wild variety has been poorly investigated. This study evaluates the biological activities of the ethanol/water extract of aerial parts and correlates these activities with the presence of phenolic compounds. The extract exhibited antioxidant activity in the four assays (DPPH, reducing power, B-carotene bleaching and TBARS). The key role of oxidative stress in inflammation and tumorigenesis was supported by the results of anti-inflammatory (inhibition of nitric oxide production) and cytotoxicity (human tumor cell lines, namely HeLa, HepG2, MCF-7, and NCI-H460) assays. In contrast, no toxicity was observed in non-tumor cells. In the antibacterial screening, clinical resistant isolates were significantly affected (MIC50 = 10–0.625 microg/mL), being Listeria monocytogenes the most susceptible. Three phenolic acids and eleven flavonol glycosides derivatives were identified, quercetin-3-O-pentosylhexoside being the most abundant.
ER -
SVOBODOVÁ, Blanka, Lillian BARROS, Ricardo C. CALHELHA, Sandrina HELENO, Maria Jose ALVES, Simone WALCOTT, Miroslava BITTOVÁ, Vlastimil KUBÁŇ and Isabel C.F.R. FERREIRA. Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago. \textit{Industrial Crops and Products}. AMSTERDAM: ELSEVIER SCIENCE BV, 2017, vol.~95, January, p.~365-373. ISSN~0926-6690. Available from: https://dx.doi.org/10.1016/j.indcrop.2016.10.046.
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