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@article{1366834, author = {Svobodová, Blanka and Barros, Lillian and Calhelha, Ricardo C. and Heleno, Sandrina and Alves, Maria Jose and Walcott, Simone and Bittová, Miroslava and Kubáň, Vlastimil and Ferreira, Isabel C.F.R.}, article_location = {AMSTERDAM}, article_number = {January}, doi = {http://dx.doi.org/10.1016/j.indcrop.2016.10.046}, keywords = {Antioxidant; Anti-inflammatory; Antimicrobial activity; Cytotoxicity; Phenolic compounds; Momordica charantia L.}, language = {eng}, issn = {0926-6690}, journal = {Industrial Crops and Products}, title = {Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago}, url = {http://www.sciencedirect.com/science/article/pii/S0926669016307336}, volume = {95}, year = {2017} }
TY - JOUR ID - 1366834 AU - Svobodová, Blanka - Barros, Lillian - Calhelha, Ricardo C. - Heleno, Sandrina - Alves, Maria Jose - Walcott, Simone - Bittová, Miroslava - Kubáň, Vlastimil - Ferreira, Isabel C.F.R. PY - 2017 TI - Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago JF - Industrial Crops and Products VL - 95 IS - January SP - 365-373 EP - 365-373 PB - ELSEVIER SCIENCE BV SN - 09266690 KW - Antioxidant KW - Anti-inflammatory KW - Antimicrobial activity KW - Cytotoxicity KW - Phenolic compounds KW - Momordica charantia L. UR - http://www.sciencedirect.com/science/article/pii/S0926669016307336 L2 - http://www.sciencedirect.com/science/article/pii/S0926669016307336 N2 - A wild variety of bitter melon Momordica charantia L. (Cucurbitaceae) has been used in bush medicine of Trinidad and Tobago for treatment of diabetes, inflammations and cancer. Despite many studies regarding the cultivated bitter melon, the wild variety has been poorly investigated. This study evaluates the biological activities of the ethanol/water extract of aerial parts and correlates these activities with the presence of phenolic compounds. The extract exhibited antioxidant activity in the four assays (DPPH, reducing power, B-carotene bleaching and TBARS). The key role of oxidative stress in inflammation and tumorigenesis was supported by the results of anti-inflammatory (inhibition of nitric oxide production) and cytotoxicity (human tumor cell lines, namely HeLa, HepG2, MCF-7, and NCI-H460) assays. In contrast, no toxicity was observed in non-tumor cells. In the antibacterial screening, clinical resistant isolates were significantly affected (MIC50 = 10–0.625 microg/mL), being Listeria monocytogenes the most susceptible. Three phenolic acids and eleven flavonol glycosides derivatives were identified, quercetin-3-O-pentosylhexoside being the most abundant. ER -
SVOBODOVÁ, Blanka, Lillian BARROS, Ricardo C. CALHELHA, Sandrina HELENO, Maria Jose ALVES, Simone WALCOTT, Miroslava BITTOVÁ, Vlastimil KUBÁŇ and Isabel C.F.R. FERREIRA. Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago. \textit{Industrial Crops and Products}. AMSTERDAM: ELSEVIER SCIENCE BV, 2017, vol.~95, January, p.~365-373. ISSN~0926-6690. Available from: https://dx.doi.org/10.1016/j.indcrop.2016.10.046.
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