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@article{1367107,
author = {Novák, Jan and Šána, Jiří and Stračina, Tibor and Nováková, Marie and Slabý, Ondřej},
article_location = {Totowa},
article_number = {3},
doi = {http://dx.doi.org/10.1007/s12012-016-9393-8},
keywords = {Cardiotoxicity; Doxorubicin; let-7g; lipodox; microRNAs; miR-208a},
language = {eng},
issn = {1530-7905},
journal = {Cardiovascular Toxicology},
title = {Doxorubicin and Liposomal Doxorubicin Differentially Affect Expression of miR-208a and let-7g in Rat Ventricles and Atria},
volume = {17},
year = {2017}
}
TY - JOUR
ID - 1367107
AU - Novák, Jan - Šána, Jiří - Stračina, Tibor - Nováková, Marie - Slabý, Ondřej
PY - 2017
TI - Doxorubicin and Liposomal Doxorubicin Differentially Affect Expression of miR-208a and let-7g in Rat Ventricles and Atria
JF - Cardiovascular Toxicology
VL - 17
IS - 3
SP - 355-359
EP - 355-359
PB - Humana Press
SN - 15307905
KW - Cardiotoxicity
KW - Doxorubicin
KW - let-7g
KW - lipodox
KW - microRNAs
KW - miR-208a
N2 - Anthracyclines use is limited by profound cardiotoxicity. Involvement of miRNAs in anthracycline-induced cardiotoxicity (AIC) is still not completely understood. Thus, the expression of AIC-related microRNAs was determined in rat atria and ventricles after doxorubicin (DOX) and liposomal doxorubicin (L-DOX) administration. Vehiculum, DOX or L-DOX were applied intraperitoneally in a single dose to male Wistar rats (3 groups: control, DOX and L-DOX, respectively). Rats were sacrificed after 24 h, and samples from left atrium (LA)/ventricle (LV) and right atrium (RA)/ventricle (RV) were obtained. Expressions of miR-208a, let-7g and snU6 were determined using qRT-PCR. In the control group, miR-208a was highly abundant in the atria compared to the ventricles and in the left-sided structures compared to the right-sided structures, while let-7g showed only atrio-ventricular gradient with predominant expression in the atria. Administration of both DOX and L-DOX resulted in 38.87 and 23.57% reduction in miR-208a expression in the LV (p = 0.028) and in 13.79 and 14.70% reduction in let-7g expression in the LA (p = 0.015), respectively. Acute administration of DOX/L-DOX alters expression of miR-208a in LV and of let-7g in LA. These changes may partly contribute to the development of AIC.
ER -
NOVÁK, Jan, Jiří ŠÁNA, Tibor STRAČINA, Marie NOVÁKOVÁ and Ondřej SLABÝ. Doxorubicin and Liposomal Doxorubicin Differentially Affect Expression of miR-208a and let-7g in Rat Ventricles and Atria. \textit{Cardiovascular Toxicology}. Totowa: Humana Press, 2017, vol.~17, No~3, p.~355-359. ISSN~1530-7905. Available from: https://dx.doi.org/10.1007/s12012-016-9393-8.
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