Pre-treatment VD levels and VDR receptors as potential
predictors of occurrence and overall survival in paediatric
patients with solid tumours-a single institution pilot study

J 2016

Pre-treatment VD levels and VDR receptors as potential predictors of occurrence and overall survival in paediatric patients with solid tumours-a single institution pilot study

BIENERTOVÁ VAŠKŮ, Julie, Klára DRÁBOVÁ, Filip ZLÁMAL, Josef TOMANDL, Michal KÝR et. al.

Basic information

Original name

Pre-treatment VD levels and VDR receptors as potential predictors of occurrence and overall survival in paediatric patients with solid tumours-a single institution pilot study

Authors

BIENERTOVÁ VAŠKŮ, Julie (203 Czech Republic, belonging to the institution), Klára DRÁBOVÁ (203 Czech Republic), Filip ZLÁMAL (203 Czech Republic, belonging to the institution), Josef TOMANDL (203 Czech Republic, belonging to the institution), Michal KÝR (203 Czech Republic), Zbyněk ŠPLÍCHAL (203 Czech Republic, belonging to the institution) and Jaroslav ŠTĚRBA (203 Czech Republic, guarantor)

Edition

Tumor Biology, Dordrecht, Springer, 2016, 1010-4283

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.650

RIV identification code

RIV/00216224:14110/16:00092763

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s13277-016-4820-9

UT WoS

000382174500072

Keywords in English

Vitamin D; Childhood cancer; Overall survival; VDR; Gene; SNP

Abstract

V originále

Recently, vitamin D has been recognized as an important player in the immune system, and multiple studies suggested its involvement in cancer, too. The aims of this study were to investigate selected single nucleotide polymorphisms (SNPs) in the VDR gene, BsmI (rs1544410; A > G), FokI (rs 2228570; C > T), TaqI (rs731236; T > C), ApaI (rs 7975232; C > T) and Cdx-2 (rs11568820; A > G), and to evaluate their possible predictive role for outcomes in patients with paediatric solid tumours. A total of 111 children with paediatric solid tumours were enrolled at the Department of Paediatric Oncology, University Hospital Brno (Brno, Czech Republic) along with a control population of 787 adults; all study subjects were available for genotyping of selected SNPs, and the prediagnostic levels of 25-hydroxycholecalciferol (25(OH)D3) and 1,25-dihydroxycholecalciferol (1,25(OH)2D3) were measured in the cases, too. In FokI, the heterozygote CT genotype was weakly associated with a decreased risk of paediatric solid cancer occurrence 0.82 (0.53-1.28), while the CC genotype was associated with a decreased risk of 0.58 (0.30-1.09), p = 0.09. The 1,25(OH)2D3 prediagnostic levels were indicative of the overall survival in the cases (beta = -0.012, HR 0.988, 95 % CI (0.978-0.998), while higher prediagnostic levels of 1,25(OH)2D3 were associated with a statistically significant increase in overall mortality. We observed multiple effects of the alleles of the investigated polymorphisms and of 1,25(OH)2D3 on overall survival, regardless of the underlying disease.

Links

EF15_003/0000469, research and development project

Name: Cetocoen Plus

LM2011028, research and development project

Name: RECETOX ? Národní infrastruktura pro výzkum toxických látek v prostředí

Investor: Ministry of Education, Youth and Sports of the CR

Files attached

EL_1367260.pdf

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Citovat

BIENERTOVÁ VAŠKŮ, Julie, Klára DRÁBOVÁ, Filip ZLÁMAL, Josef TOMANDL, Michal KÝR, Zbyněk ŠPLÍCHAL and Jaroslav ŠTĚRBA. Pre-treatment VD levels and VDR receptors as potential predictors of occurrence and overall survival in paediatric patients with solid tumours-a single institution pilot study. Tumor Biology. Dordrecht: Springer, 2016, vol. 37, No 7, p. 9209-9219. ISSN 1010-4283. Available from: https://dx.doi.org/10.1007/s13277-016-4820-9.

@article{1367260,
   author = {Bienertová Vašků, Julie and Drábová, Klára and Zlámal, Filip and Tomandl, Josef and Kýr, Michal and Šplíchal, Zbyněk and Štěrba, Jaroslav},
   article_location = {Dordrecht},
   article_number = {7},
   doi = {http://dx.doi.org/10.1007/s13277-016-4820-9},
   keywords = {Vitamin D; Childhood cancer; Overall survival; VDR; Gene; SNP},
   language = {eng},
   issn = {1010-4283},
   journal = {Tumor Biology},
   title = {Pre-treatment VD levels and VDR receptors as potential predictors of occurrence and overall survival in paediatric patients with solid tumours-a single institution pilot study},
   volume = {37},
   year = {2016}
}

TY  - JOUR
ID  - 1367260
AU  - Bienertová Vašků, Julie - Drábová, Klára - Zlámal, Filip - Tomandl, Josef - Kýr, Michal - Šplíchal, Zbyněk - Štěrba, Jaroslav
PY  - 2016
TI  - Pre-treatment VD levels and VDR receptors as potential predictors of occurrence and overall survival in paediatric patients with solid tumours-a single institution pilot study
JF  - Tumor Biology
VL  - 37
IS  - 7
SP  - 9209-9219
EP  - 9209-9219
PB  - Springer
SN  - 10104283
KW  - Vitamin D
KW  - Childhood cancer
KW  - Overall survival
KW  - VDR
KW  - Gene
KW  - SNP
N2  - Recently, vitamin D has been recognized as an important player in the immune system, and multiple studies suggested its involvement in cancer, too. The aims of this study were to investigate selected single nucleotide polymorphisms (SNPs) in the VDR gene, BsmI (rs1544410; A > G), FokI (rs 2228570; C > T), TaqI (rs731236; T > C), ApaI (rs 7975232; C > T) and Cdx-2 (rs11568820; A > G), and to evaluate their possible predictive role for outcomes in patients with paediatric solid tumours. A total of 111 children with paediatric solid tumours were enrolled at the Department of Paediatric Oncology, University Hospital Brno (Brno, Czech Republic) along with a control population of 787 adults; all study subjects were available for genotyping of selected SNPs, and the prediagnostic levels of 25-hydroxycholecalciferol (25(OH)D3) and 1,25-dihydroxycholecalciferol (1,25(OH)2D3) were measured in the cases, too. In FokI, the heterozygote CT genotype was weakly associated with a decreased risk of paediatric solid cancer occurrence 0.82 (0.53-1.28), while the CC genotype was associated with a decreased risk of 0.58 (0.30-1.09), p = 0.09. The 1,25(OH)2D3 prediagnostic levels were indicative of the overall survival in the cases (beta = -0.012, HR 0.988, 95 % CI (0.978-0.998), while higher prediagnostic levels of 1,25(OH)2D3 were associated with a statistically significant increase in overall mortality. We observed multiple effects of the alleles of the investigated polymorphisms and of 1,25(OH)2D3 on overall survival, regardless of the underlying disease.
ER  -

BIENERTOVÁ VAŠKŮ, Julie, Klára DRÁBOVÁ, Filip ZLÁMAL, Josef TOMANDL, Michal KÝR, Zbyněk ŠPLÍCHAL and Jaroslav ŠTĚRBA. Pre-treatment VD levels and VDR receptors as potential predictors of occurrence and overall survival in paediatric patients with solid tumours-a single institution pilot study. \textit{Tumor Biology}. Dordrecht: Springer, 2016, vol.~37, No~7, p.~9209-9219. ISSN~1010-4283. Available from: https://dx.doi.org/10.1007/s13277-016-4820-9.

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