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@article{1367295,
author = {Pail, Martin and Řehulka, Pavel and Cimbálník, Jan and Doležalová, Irena and Chrastina, Jan and Brázdil, Milan},
article_location = {Clare},
article_number = {1},
doi = {http://dx.doi.org/10.1016/j.clinph.2016.10.011},
keywords = {Epileptogenic zone; Extratemporal lobe epilepsy; Fast ripples; High frequency oscillations; Irritative zone; Ripples; Seizure onset zone; Temporal lobe epilepsy},
language = {eng},
issn = {1388-2457},
journal = {Clinical Neurophysiology},
title = {Frequency-independent characteristics of high-frequency oscillations in epileptic and non-epileptic regions},
volume = {128},
year = {2017}
}
TY - JOUR
ID - 1367295
AU - Pail, Martin - Řehulka, Pavel - Cimbálník, Jan - Doležalová, Irena - Chrastina, Jan - Brázdil, Milan
PY - 2017
TI - Frequency-independent characteristics of high-frequency oscillations in epileptic and non-epileptic regions
JF - Clinical Neurophysiology
VL - 128
IS - 1
SP - 106-114
EP - 106-114
PB - Elsevier Ireland Ltd.
SN - 13882457
KW - Epileptogenic zone
KW - Extratemporal lobe epilepsy
KW - Fast ripples
KW - High frequency oscillations
KW - Irritative zone
KW - Ripples
KW - Seizure onset zone
KW - Temporal lobe epilepsy
N2 - Objective The purpose of the presented study is to determine whether there are frequency-independent high-frequency oscillation (HFO) parameters which may differ in epileptic and non-epileptic regions. Methods We studied 31 consecutive patients with medically intractable focal (temporal and extratemporal) epilepsies who were examined by either intracerebral or subdural electrodes. Automated detection was used to detect HFO. The characteristics (rate, amplitude, and duration) of HFO were statistically compared within three groups: the seizure onset zone (SOZ), the irritative zone (IZ), and areas outside the IZ and SOZ (nonSOZ/nonIZ). Results In all patients, fast ripples (FR) and ripples (R) were significantly more frequent and shorter in the SOZ than in the nonSOZ/nonIZ region. In the group of patients with favorable surgical outcomes, the relative amplitude of FR was higher in the SOZ than in the IZ and nonIZ/nonSOZ regions; in patients with poor outcomes, the results were reversed. The relative amplitude of R was significantly higher in the SOZ, with no difference between patients with poor and favorable surgical outcomes. Conclusions FR are more frequent, shorter, and have higher relative amplitudes in the SOZ area than in other regions. The study suggests a worse prognosis in patients with higher amplitudes of FR outside the SOZ. Significance Various HFO parameters, especially of FR, differ in epileptic and non-epileptic regions. The amplitude and duration may be as important as the frequency band and rate of HFO in marking the seizure onset region or the epileptogenic area and may provide additional information on epileptogenicity.
ER -
PAIL, Martin, Pavel ŘEHULKA, Jan CIMBÁLNÍK, Irena DOLEŽALOVÁ, Jan CHRASTINA and Milan BRÁZDIL. Frequency-independent characteristics of high-frequency oscillations in epileptic and non-epileptic regions. \textit{Clinical Neurophysiology}. Clare: Elsevier Ireland Ltd., 2017, vol.~128, No~1, p.~106-114. ISSN~1388-2457. Available from: https://dx.doi.org/10.1016/j.clinph.2016.10.011.
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