J 2017

Frequency-independent characteristics of high-frequency oscillations in epileptic and non-epileptic regions

PAIL, Martin, Pavel ŘEHULKA, Jan CIMBÁLNÍK, Irena DOLEŽALOVÁ, Jan CHRASTINA et. al.

Basic information

Original name

Frequency-independent characteristics of high-frequency oscillations in epileptic and non-epileptic regions

Authors

PAIL, Martin (203 Czech Republic, guarantor, belonging to the institution), Pavel ŘEHULKA (203 Czech Republic), Jan CIMBÁLNÍK (203 Czech Republic), Irena DOLEŽALOVÁ (203 Czech Republic, belonging to the institution), Jan CHRASTINA (203 Czech Republic) and Milan BRÁZDIL (203 Czech Republic, belonging to the institution)

Edition

Clinical Neurophysiology, Clare, Elsevier Ireland Ltd. 2017, 1388-2457

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.614

RIV identification code

RIV/00216224:14110/17:00094601

Organization unit

Faculty of Medicine

DOI

UT WoS

000396377300011

Keywords in English

Epileptogenic zone; Extratemporal lobe epilepsy; Fast ripples; High frequency oscillations; Irritative zone; Ripples; Seizure onset zone; Temporal lobe epilepsy

Tags

Tags

International impact, Reviewed
Změněno: 20/3/2018 18:17, Soňa Böhmová

Abstract

V originále

Objective The purpose of the presented study is to determine whether there are frequency-independent high-frequency oscillation (HFO) parameters which may differ in epileptic and non-epileptic regions. Methods We studied 31 consecutive patients with medically intractable focal (temporal and extratemporal) epilepsies who were examined by either intracerebral or subdural electrodes. Automated detection was used to detect HFO. The characteristics (rate, amplitude, and duration) of HFO were statistically compared within three groups: the seizure onset zone (SOZ), the irritative zone (IZ), and areas outside the IZ and SOZ (nonSOZ/nonIZ). Results In all patients, fast ripples (FR) and ripples (R) were significantly more frequent and shorter in the SOZ than in the nonSOZ/nonIZ region. In the group of patients with favorable surgical outcomes, the relative amplitude of FR was higher in the SOZ than in the IZ and nonIZ/nonSOZ regions; in patients with poor outcomes, the results were reversed. The relative amplitude of R was significantly higher in the SOZ, with no difference between patients with poor and favorable surgical outcomes. Conclusions FR are more frequent, shorter, and have higher relative amplitudes in the SOZ area than in other regions. The study suggests a worse prognosis in patients with higher amplitudes of FR outside the SOZ. Significance Various HFO parameters, especially of FR, differ in epileptic and non-epileptic regions. The amplitude and duration may be as important as the frequency band and rate of HFO in marking the seizure onset region or the epileptogenic area and may provide additional information on epileptogenicity.

Links

ED1.1.00/02.0068, research and development project
Name: CEITEC - central european institute of technology
GAP103/11/0933, research and development project
Name: Analýza vysokofrekvenčního EEG signálu z hlubokých mozkových elektrod
Investor: Czech Science Foundation
MSM0021622404, plan (intention)
Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.