The Role of microRNA in Ischemic and Hemorrhagic Stroke

J 2017

The Role of microRNA in Ischemic and Hemorrhagic Stroke

LIPKOVÁ, Jolana and Kamil ĎURIŠ

Basic information

Original name

The Role of microRNA in Ischemic and Hemorrhagic Stroke

Name in Czech

Role microRNA u ischemické a hemoragické cévní mozkové příhody

Authors

LIPKOVÁ, Jolana (203 Czech Republic, guarantor, belonging to the institution) and Kamil ĎURIŠ (203 Czech Republic, belonging to the institution)

Edition

Current Drug Delivery, Sharjah, Bentham Science Publishers, 2017, 1567-2018

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United Arab Emirates

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.078

RIV identification code

RIV/00216224:14110/17:00094602

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.2174/1567201813666160919142212

UT WoS

000409883200010

Keywords (in Czech)

microRNA, ischemické cévní mozková příhoda, hemoragická cévní mozková příhoda

Keywords in English

Central nervous system; embolectomies; hemorrgahic stroke; ischemic stroke; microRNA; thrombolysis

Abstract

V originále

Background: Stroke is the second leading cause of death worldwide. Understanding of gene expression dynamics could bring new approaches in diagnostics and therapy of stroke. Small noncoding molecules termed "microRNA" represent the most flexible network of gene expression regulators. Method: The aim of this review was to briefly describe the structure and function of microRNA and summarize the current knowledge about the involvement of microRNAs in the pathophysiology of ischemic and hemorrhagic stroke based on both experimental and clinical studies. Results: Numerous profiling studies identified candidate microRNAs and partially described dynamics of their expression after the stroke. However, complex associations of specific microRNAs expression with main clinical characteristics and deeper insight into mechanisms of their regulatory functions are still missing. In this review, we put special emphasis on several microRNA clusters involved in neuroprotection (miR-124, miR-181, miR-21, miR-29, miR-210 and let7). Potential application of microRNAs as biomarkers and diagnostic or therapeutic targets was also discussed. Conclusion: Full understanding of the regulatory mechanisms of the microRNA networks represents a novel direction for stroke research. To date, we do not have effective tools to control pathophysiological processes associated with stroke. Thus the microRNAs have to be considered as a very promising target for future stroke therapies.

Links

GP14-23773P, research and development project

Name: Regulace zánětlivé odpovědi prostřednictvím mikroRNA na experimaentálním modelu subarachnoidálního krvácení

Investor: Czech Science Foundation

Citovat

LIPKOVÁ, Jolana and Kamil ĎURIŠ. The Role of microRNA in Ischemic and Hemorrhagic Stroke (The role of microRNA in ischemic and hemorrhagic stroke). Current Drug Delivery. Sharjah: Bentham Science Publishers, 2017, vol. 14, No 6, p. 816-831. ISSN 1567-2018. Available from: https://dx.doi.org/10.2174/1567201813666160919142212.

@article{1367388,
   author = {Lipková, Jolana and Ďuriš, Kamil},
   article_location = {Sharjah},
   article_number = {6},
   doi = {http://dx.doi.org/10.2174/1567201813666160919142212},
   keywords = {Central nervous system; embolectomies; hemorrgahic stroke; ischemic stroke; microRNA; thrombolysis},
   language = {eng},
   issn = {1567-2018},
   journal = {Current Drug Delivery},
   title = {The Role of microRNA in Ischemic and Hemorrhagic Stroke},
   volume = {14},
   year = {2017}
}

TY  - JOUR
ID  - 1367388
AU  - Lipková, Jolana - Ďuriš, Kamil
PY  - 2017
TI  - The Role of microRNA in Ischemic and Hemorrhagic Stroke
JF  - Current Drug Delivery
VL  - 14
IS  - 6
SP  - 816-831
EP  - 816-831
PB  - Bentham Science Publishers
SN  - 15672018
KW  - Central nervous system
KW  - embolectomies
KW  - hemorrgahic stroke
KW  - ischemic stroke
KW  - microRNA
KW  - thrombolysis
N2  - Background: Stroke is the second leading cause of death worldwide. Understanding of gene expression dynamics could bring new approaches in diagnostics and therapy of stroke. Small noncoding molecules termed "microRNA" represent the most flexible network of gene expression regulators. Method: The aim of this review was to briefly describe the structure and function of microRNA and summarize the current knowledge about the involvement of microRNAs in the pathophysiology of ischemic and hemorrhagic stroke based on both experimental and clinical studies. Results: Numerous profiling studies identified candidate microRNAs and partially described dynamics of their expression after the stroke. However, complex associations of specific microRNAs expression with main clinical characteristics and deeper insight into mechanisms of their regulatory functions are still missing. In this review, we put special emphasis on several microRNA clusters involved in neuroprotection (miR-124, miR-181, miR-21, miR-29, miR-210 and let7). Potential application of microRNAs as biomarkers and diagnostic or therapeutic targets was also discussed. Conclusion: Full understanding of the regulatory mechanisms of the microRNA networks represents a novel direction for stroke research. To date, we do not have effective tools to control pathophysiological processes associated with stroke. Thus the microRNAs have to be considered as a very promising target for future stroke therapies.
ER  -

LIPKOVÁ, Jolana and Kamil ĎURIŠ. The Role of microRNA in Ischemic and Hemorrhagic Stroke (The role of microRNA in ischemic and hemorrhagic stroke). \textit{Current Drug Delivery}. Sharjah: Bentham Science Publishers, 2017, vol.~14, No~6, p.~816-831. ISSN~1567-2018. Available from: https://dx.doi.org/10.2174/1567201813666160919142212.

Detailed Information on Publication Record